Needle-Free Jet Injectors’ Geometry Design and Drug Diffusion Process Analysis
In order to study the injection and diffusion process of the drug in the subcutaneous tissue of a needle-free jet injectors (NFJIs) in detail and understand the influence of different nozzle geometry on the diffusion process of the drug, in this paper, numerical simulations were performed to study t...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Applied Bionics and Biomechanics |
| Online Access: | http://dx.doi.org/10.1155/2021/5199278 |
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| author | Yunfei Wang Long Yue Lechuan Hu Jing Wang |
| author_facet | Yunfei Wang Long Yue Lechuan Hu Jing Wang |
| author_sort | Yunfei Wang |
| collection | DOAJ |
| description | In order to study the injection and diffusion process of the drug in the subcutaneous tissue of a needle-free jet injectors (NFJIs) in detail and understand the influence of different nozzle geometry on the diffusion process of the drug, in this paper, numerical simulations were performed to study the diffusion process of the drug in the subcutaneous tissue of NFJIs with cylindrical nozzle. On this basis, the differences of the drug diffusion process with different nozzle geometries were analyzed. The results show that the drug diffused in the shape of ellipsoid in the subcutaneous tissue. The penetration of the drug into the subcutaneous tissue is deeper under the condition of conical nozzle and conical cylindrical nozzle at the same time. However, it takes longer to spread to the interface between skin and subcutaneous tissue in reverse. |
| format | Article |
| id | doaj-art-802263068d014e7680a1ec50d4eb6f2f |
| institution | Kabale University |
| issn | 1754-2103 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Applied Bionics and Biomechanics |
| spelling | doaj-art-802263068d014e7680a1ec50d4eb6f2f2025-02-03T01:06:53ZengWileyApplied Bionics and Biomechanics1754-21032021-01-01202110.1155/2021/5199278Needle-Free Jet Injectors’ Geometry Design and Drug Diffusion Process AnalysisYunfei Wang0Long Yue1Lechuan Hu2Jing Wang3School of Transportation and Vehicle EngineeringSchool of Transportation and Vehicle EngineeringSchool of Energy and Power EngineeringSchool of Clinical MedicineIn order to study the injection and diffusion process of the drug in the subcutaneous tissue of a needle-free jet injectors (NFJIs) in detail and understand the influence of different nozzle geometry on the diffusion process of the drug, in this paper, numerical simulations were performed to study the diffusion process of the drug in the subcutaneous tissue of NFJIs with cylindrical nozzle. On this basis, the differences of the drug diffusion process with different nozzle geometries were analyzed. The results show that the drug diffused in the shape of ellipsoid in the subcutaneous tissue. The penetration of the drug into the subcutaneous tissue is deeper under the condition of conical nozzle and conical cylindrical nozzle at the same time. However, it takes longer to spread to the interface between skin and subcutaneous tissue in reverse.http://dx.doi.org/10.1155/2021/5199278 |
| spellingShingle | Yunfei Wang Long Yue Lechuan Hu Jing Wang Needle-Free Jet Injectors’ Geometry Design and Drug Diffusion Process Analysis Applied Bionics and Biomechanics |
| title | Needle-Free Jet Injectors’ Geometry Design and Drug Diffusion Process Analysis |
| title_full | Needle-Free Jet Injectors’ Geometry Design and Drug Diffusion Process Analysis |
| title_fullStr | Needle-Free Jet Injectors’ Geometry Design and Drug Diffusion Process Analysis |
| title_full_unstemmed | Needle-Free Jet Injectors’ Geometry Design and Drug Diffusion Process Analysis |
| title_short | Needle-Free Jet Injectors’ Geometry Design and Drug Diffusion Process Analysis |
| title_sort | needle free jet injectors geometry design and drug diffusion process analysis |
| url | http://dx.doi.org/10.1155/2021/5199278 |
| work_keys_str_mv | AT yunfeiwang needlefreejetinjectorsgeometrydesignanddrugdiffusionprocessanalysis AT longyue needlefreejetinjectorsgeometrydesignanddrugdiffusionprocessanalysis AT lechuanhu needlefreejetinjectorsgeometrydesignanddrugdiffusionprocessanalysis AT jingwang needlefreejetinjectorsgeometrydesignanddrugdiffusionprocessanalysis |