ST2/IL-33 axis blockade inhibits regulatory T cell cytotoxicity towards CD8 T cells in the leukemic niche

ST2/IL-33 axis blockade inhibits regulatory T cell cytotoxicity towards CD8 T cells in the leukemic niche

Abstract Acute myeloid leukemia (AML) patients present with CD8 exhaustion signatures, and pharmacologic inhibition of checkpoints can have therapeutic benefit. The alarmin IL-33 and its receptor STimulation-2 (ST2) promote activation of tissue-regulatory T cells (Treg cells) and accelerate malignan...

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Main Authors: Hua Jiang, Denggang Fu, Santhosh Kumar Pasupuleti, Baskar Ramdas, Alan Long, Abdulraouf M. Ramadan, Jinfeng Yang, Ramesh Kumar, Jessica H. Hartman, B. Jacob Kendrick, Ed Simpson, Hongyu Gao, Yunlong Liu, Drew Moore, Suganya Subramanian, Stefano Berto, Anilkumar Gopalakrishnapillai, Sonali P. Barwe, Hongfen Guo, Nai-Kong V. Cheung, Reuben Kapur, Sophie Paczesny
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-61647-8
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https://doi.org/10.1038/s41467-025-61647-8

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