Daily activity, mood, and quality of life in colorectal cancer patients with chemotherapy‐induced peripheral neuropathy: A mediation effect analysis
Abstract Chemotherapy‐induced peripheral neuropathy (CIPN) with restriction of daily activity (RDA) was common consequence of oxaliplatin‐based chemotherapy in colorectal cancer patients. CIPN with RDA and negative mood may impact the quality of life (QoL). However, the relationships among RDA, mood...
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Wiley
2019-03-01
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| Series: | Cancer Medicine |
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| Online Access: | https://doi.org/10.1002/cam4.1976 |
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| author | Ling‐Chun Lu Shiow‐Luan Tsay Sou‐Yi Chang Chung‐Ming Chen Chieh‐Yu Liu |
| author_facet | Ling‐Chun Lu Shiow‐Luan Tsay Sou‐Yi Chang Chung‐Ming Chen Chieh‐Yu Liu |
| author_sort | Ling‐Chun Lu |
| collection | DOAJ |
| description | Abstract Chemotherapy‐induced peripheral neuropathy (CIPN) with restriction of daily activity (RDA) was common consequence of oxaliplatin‐based chemotherapy in colorectal cancer patients. CIPN with RDA and negative mood may impact the quality of life (QoL). However, the relationships among RDA, mood, and QoL remain unclear. This was a cross‐sectional relative study in which four instruments were used: the Neuropathic Pain Symptom Inventory was used to measure the severity of CIPN; the Screening of Activity Limitation and Safety Awareness scale was used to evaluate RDA; the Profile of Mood States Short Form was used to assess negative mood; and the Functional Assessment Cancer Center Therapy‐Colorectal scale version 4 was used to evaluate QoL. Relationships among the variables were analyzed by bivariate correlation, hierarchical multiple linear regression, and Baron and Kenny's mediation testing. One hundred three colorectal adenocarcinoma patients with CIPN after receiving oxaliplatin‐based chemotherapy were enrolled. Patients had mild‐to‐moderate CIPN and mild RDA. Significant correlations were found between CIPN and mood (r = 0.425, P < 0.001), between RDA and mood (r = 0.343, P < 0.001), and between RDA and QoL (r = 0.285, P < 0.01). RDA and mood may impact QoL. Under mediation effect analysis, mood mediated 38.48% of the effect of RDA on QoL (P < 0.001). Negative mood is the major factor impacting QoL in colorectal cancer patients with CIPN. Although the management of CIPN and RDA can prevent irreversible functional problems, enhancing the adaption of mood disturbance can strongly promote their QoL. |
| format | Article |
| id | doaj-art-7fc6f8454ad244ff82928d39237e6ea7 |
| institution | Kabale University |
| issn | 2045-7634 |
| language | English |
| publishDate | 2019-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cancer Medicine |
| spelling | doaj-art-7fc6f8454ad244ff82928d39237e6ea72025-01-31T08:47:42ZengWileyCancer Medicine2045-76342019-03-018396397110.1002/cam4.1976Daily activity, mood, and quality of life in colorectal cancer patients with chemotherapy‐induced peripheral neuropathy: A mediation effect analysisLing‐Chun Lu0Shiow‐Luan Tsay1Sou‐Yi Chang2Chung‐Ming Chen3Chieh‐Yu Liu4School of Nursing National Taipei University of Nursing and Health Sciences, Nurse Practitioner, Koo Foundation, Sun Yat‐Sen Cancer Center Taipei City Taiwan (R.O.C.)College of Nursing and Health Sciences Da‐Yeh University Changhua County Taiwan (R.O.C.)Department of Hematology and Oncology Taipei Tzu Chi Hospital New Taipei City Taiwan (R.O.C.)Department of Colorectal Surgery Hualien Tzu Chi Hospital Hualien County Taiwan (R.O.C.)Biostatistical Consultant Lab, Department of Speech Language Pathology and Audiology National Taipei University of Nursing and Health Sciences Taipei City Taiwan (R.O.C.)Abstract Chemotherapy‐induced peripheral neuropathy (CIPN) with restriction of daily activity (RDA) was common consequence of oxaliplatin‐based chemotherapy in colorectal cancer patients. CIPN with RDA and negative mood may impact the quality of life (QoL). However, the relationships among RDA, mood, and QoL remain unclear. This was a cross‐sectional relative study in which four instruments were used: the Neuropathic Pain Symptom Inventory was used to measure the severity of CIPN; the Screening of Activity Limitation and Safety Awareness scale was used to evaluate RDA; the Profile of Mood States Short Form was used to assess negative mood; and the Functional Assessment Cancer Center Therapy‐Colorectal scale version 4 was used to evaluate QoL. Relationships among the variables were analyzed by bivariate correlation, hierarchical multiple linear regression, and Baron and Kenny's mediation testing. One hundred three colorectal adenocarcinoma patients with CIPN after receiving oxaliplatin‐based chemotherapy were enrolled. Patients had mild‐to‐moderate CIPN and mild RDA. Significant correlations were found between CIPN and mood (r = 0.425, P < 0.001), between RDA and mood (r = 0.343, P < 0.001), and between RDA and QoL (r = 0.285, P < 0.01). RDA and mood may impact QoL. Under mediation effect analysis, mood mediated 38.48% of the effect of RDA on QoL (P < 0.001). Negative mood is the major factor impacting QoL in colorectal cancer patients with CIPN. Although the management of CIPN and RDA can prevent irreversible functional problems, enhancing the adaption of mood disturbance can strongly promote their QoL.https://doi.org/10.1002/cam4.1976chemotherapy‐induced peripheral neuropathydaily activitymediation effect analysismoodquality of life |
| spellingShingle | Ling‐Chun Lu Shiow‐Luan Tsay Sou‐Yi Chang Chung‐Ming Chen Chieh‐Yu Liu Daily activity, mood, and quality of life in colorectal cancer patients with chemotherapy‐induced peripheral neuropathy: A mediation effect analysis Cancer Medicine chemotherapy‐induced peripheral neuropathy daily activity mediation effect analysis mood quality of life |
| title | Daily activity, mood, and quality of life in colorectal cancer patients with chemotherapy‐induced peripheral neuropathy: A mediation effect analysis |
| title_full | Daily activity, mood, and quality of life in colorectal cancer patients with chemotherapy‐induced peripheral neuropathy: A mediation effect analysis |
| title_fullStr | Daily activity, mood, and quality of life in colorectal cancer patients with chemotherapy‐induced peripheral neuropathy: A mediation effect analysis |
| title_full_unstemmed | Daily activity, mood, and quality of life in colorectal cancer patients with chemotherapy‐induced peripheral neuropathy: A mediation effect analysis |
| title_short | Daily activity, mood, and quality of life in colorectal cancer patients with chemotherapy‐induced peripheral neuropathy: A mediation effect analysis |
| title_sort | daily activity mood and quality of life in colorectal cancer patients with chemotherapy induced peripheral neuropathy a mediation effect analysis |
| topic | chemotherapy‐induced peripheral neuropathy daily activity mediation effect analysis mood quality of life |
| url | https://doi.org/10.1002/cam4.1976 |
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