Pathological axonal enlargement in connection with amyloidosis, lysosome destabilization, and bleeding is a major defect in Alzheimer’s disease

Pathological axonal enlargement in connection with amyloidosis, lysosome destabilization, and bleeding is a major defect in Alzheimer’s disease

Alzheimer’s disease is a multi-amyloidosis disease characterized by amyloid-β deposits in brain blood vessels, microaneurysms, and senile plaques. How amyloid-β deposition affects axon pathology has not been examined extensively. We used immunohistochemistry and immunofluorescence staining to analyz...

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Bibliographic Details
Main Authors: Hualin Fu, Jilong Li, Chunlei Zhang, Guo Gao, Qiqi Ge, Xinping Guan, Daxiang Cui
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2026-02-01
Series:Neural Regeneration Research
Subjects:
alzheimer’s disease
amyloid-β
amyloidosis
axonal enlargement
hemoglobin
hemorrhage
lysosome destabilization
neuropil thread
tau
wallerian degeneration
Online Access:https://journals.lww.com/10.4103/NRR.NRR-D-24-01440
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