Novel approaches targeting α-Synuclein for Parkinson's Disease: Current progress and future directions for the disease-modifying therapies

Novel approaches targeting α-Synuclein for Parkinson's Disease: Current progress and future directions for the disease-modifying therapies

Parkinson's Disease (PD) is a common and debilitating neurodegenerative disorder affecting millions worldwide. The hallmark pathological feature of PD is the accumulation and aggregation of α-Synuclein (α-Syn), a protein involved in synaptic function and neuronal survival. The formation of α-Sy...

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Bibliographic Details
Main Authors: David Baggett, Alex Olson, Mayur S. Parmar
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:Brain Disorders
Subjects:
Parkinson's disease
Synucleinopathy
Alpha-synuclein
Lewy body
Therapeutics
GBA
Online Access:http://www.sciencedirect.com/science/article/pii/S2666459324000489
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