Tetrahydrobiopterin in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Friend or Foe?
Myalgic Encephalomyelitis or Chronic Fatigue Syndrome (ME/CFS) is a chronic multisystem disease characterized by severe muscle fatigue, pain, dizziness, and brain fog. The two most common symptoms are post-exertional malaise (PEM) and orthostatic intolerance (OI). ME/CFS patients with OI (ME+OI) suf...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-01-01
|
| Series: | Biomolecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2218-273X/15/1/102 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832588911377907712 |
|---|---|
| author | A. F. M. Towheedur Rahman Anna Benko Sarojini Bulbule Carl Gunnar Gottschalk Leggy A. Arnold Avik Roy |
| author_facet | A. F. M. Towheedur Rahman Anna Benko Sarojini Bulbule Carl Gunnar Gottschalk Leggy A. Arnold Avik Roy |
| author_sort | A. F. M. Towheedur Rahman |
| collection | DOAJ |
| description | Myalgic Encephalomyelitis or Chronic Fatigue Syndrome (ME/CFS) is a chronic multisystem disease characterized by severe muscle fatigue, pain, dizziness, and brain fog. The two most common symptoms are post-exertional malaise (PEM) and orthostatic intolerance (OI). ME/CFS patients with OI (ME+OI) suffer from dizziness or faintness due to a sudden drop in blood pressure while maintaining an upright posture. Clinical research has demonstrated that patients with OI display severe cardiovascular abnormalities resulting in reduced effective blood flow in the cerebral blood vessels. However, despite intense investigation, it is not known why the effective cerebral blood flow is reduced in OI patients. Based on our recent findings, we observed that tetrahydrobiopterin (BH4) metabolism was highly dysregulated in ME+OI patients. In the current review article, we attempted to summarize our recent findings on BH4 metabolism to shed light on the molecular mechanisms of OI. |
| format | Article |
| id | doaj-art-7f3044a020a34c488299ca1254f9df9c |
| institution | Kabale University |
| issn | 2218-273X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj-art-7f3044a020a34c488299ca1254f9df9c2025-01-24T13:25:11ZengMDPI AGBiomolecules2218-273X2025-01-0115110210.3390/biom15010102Tetrahydrobiopterin in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Friend or Foe?A. F. M. Towheedur Rahman0Anna Benko1Sarojini Bulbule2Carl Gunnar Gottschalk3Leggy A. Arnold4Avik Roy5Milwaukee Institute for Drug Discovery, University of Wisconsin-Milwaukee, 2000 E Kenwood Blvd, Milwaukee, WI 53211, USAMilwaukee Institute for Drug Discovery, University of Wisconsin-Milwaukee, 2000 E Kenwood Blvd, Milwaukee, WI 53211, USAResearch and Development Laboratory, Chemistry Building, 2000 E Kenwood Blvd, Suite #320, Milwaukee, WI 53211, USAResearch and Development Laboratory, Chemistry Building, 2000 E Kenwood Blvd, Suite #320, Milwaukee, WI 53211, USAMilwaukee Institute for Drug Discovery, University of Wisconsin-Milwaukee, 2000 E Kenwood Blvd, Milwaukee, WI 53211, USAMilwaukee Institute for Drug Discovery, University of Wisconsin-Milwaukee, 2000 E Kenwood Blvd, Milwaukee, WI 53211, USAMyalgic Encephalomyelitis or Chronic Fatigue Syndrome (ME/CFS) is a chronic multisystem disease characterized by severe muscle fatigue, pain, dizziness, and brain fog. The two most common symptoms are post-exertional malaise (PEM) and orthostatic intolerance (OI). ME/CFS patients with OI (ME+OI) suffer from dizziness or faintness due to a sudden drop in blood pressure while maintaining an upright posture. Clinical research has demonstrated that patients with OI display severe cardiovascular abnormalities resulting in reduced effective blood flow in the cerebral blood vessels. However, despite intense investigation, it is not known why the effective cerebral blood flow is reduced in OI patients. Based on our recent findings, we observed that tetrahydrobiopterin (BH4) metabolism was highly dysregulated in ME+OI patients. In the current review article, we attempted to summarize our recent findings on BH4 metabolism to shed light on the molecular mechanisms of OI.https://www.mdpi.com/2218-273X/15/1/102tetrahydrobiopterin (BH4)dihydrobiopterin (BH2)pentose phosphate pathway (PPP)ME/CFSorthostatic intolerance (OI)oxidative stress |
| spellingShingle | A. F. M. Towheedur Rahman Anna Benko Sarojini Bulbule Carl Gunnar Gottschalk Leggy A. Arnold Avik Roy Tetrahydrobiopterin in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Friend or Foe? Biomolecules tetrahydrobiopterin (BH4) dihydrobiopterin (BH2) pentose phosphate pathway (PPP) ME/CFS orthostatic intolerance (OI) oxidative stress |
| title | Tetrahydrobiopterin in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Friend or Foe? |
| title_full | Tetrahydrobiopterin in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Friend or Foe? |
| title_fullStr | Tetrahydrobiopterin in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Friend or Foe? |
| title_full_unstemmed | Tetrahydrobiopterin in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Friend or Foe? |
| title_short | Tetrahydrobiopterin in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Friend or Foe? |
| title_sort | tetrahydrobiopterin in myalgic encephalomyelitis chronic fatigue syndrome a friend or foe |
| topic | tetrahydrobiopterin (BH4) dihydrobiopterin (BH2) pentose phosphate pathway (PPP) ME/CFS orthostatic intolerance (OI) oxidative stress |
| url | https://www.mdpi.com/2218-273X/15/1/102 |
| work_keys_str_mv | AT afmtowheedurrahman tetrahydrobiopterininmyalgicencephalomyelitischronicfatiguesyndromeafriendorfoe AT annabenko tetrahydrobiopterininmyalgicencephalomyelitischronicfatiguesyndromeafriendorfoe AT sarojinibulbule tetrahydrobiopterininmyalgicencephalomyelitischronicfatiguesyndromeafriendorfoe AT carlgunnargottschalk tetrahydrobiopterininmyalgicencephalomyelitischronicfatiguesyndromeafriendorfoe AT leggyaarnold tetrahydrobiopterininmyalgicencephalomyelitischronicfatiguesyndromeafriendorfoe AT avikroy tetrahydrobiopterininmyalgicencephalomyelitischronicfatiguesyndromeafriendorfoe |