Force transmission through the inner kinetochore is enhanced by centromeric DNA sequences

Force transmission through the inner kinetochore is enhanced by centromeric DNA sequences

Previously, we reconstituted a minimal functional kinetochore from recombinant Saccharomyces cerevisiae proteins that was capable of transmitting force from dynamic microtubules to nucleosomes containing the centromere-specific histone variant Cse4 (Hamilton et al., 2020). This work revealed two pat...

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Bibliographic Details
Main Authors: Elise Miedlar, Grace E Hamilton, Samuel R Witus, Sara J Gonske, Michael Riffle, Alex Zelter, Rachel E Klevit, Charles L Asbury, Yoana N Dimitrova, Trisha N Davis
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2025-05-01
Series:eLife
Subjects:
mitosis
centromere
kinetochore
microtubule
tension
nucleosome
Online Access:https://elifesciences.org/articles/105150
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https://elifesciences.org/articles/105150

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