Cytotoxic Phenolic Compounds from Fruit Glandular Trichomes of Macaranga tanarius
A new flavonoid, macatanarin D (1), together with five known stilbenes (2-6), was isolated from fruit glandular trichomes of Macaranga tanarius. Their structures were elucidated on the basis of spectroscopic methods and through comparison with data reported in the literature. All isolated compounds...
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| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Journal of Analytical Methods in Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2019/2917032 |
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| author | Thi Mai Huong Doan Thuy Linh Nguyen Thi Thanh Van Trinh Van Nam Vu Thi Dao Phi Marc Litaudon Fanny Roussi Van Minh Chau Van Cuong Pham |
| author_facet | Thi Mai Huong Doan Thuy Linh Nguyen Thi Thanh Van Trinh Van Nam Vu Thi Dao Phi Marc Litaudon Fanny Roussi Van Minh Chau Van Cuong Pham |
| author_sort | Thi Mai Huong Doan |
| collection | DOAJ |
| description | A new flavonoid, macatanarin D (1), together with five known stilbenes (2-6), was isolated from fruit glandular trichomes of Macaranga tanarius. Their structures were elucidated on the basis of spectroscopic methods and through comparison with data reported in the literature. All isolated compounds were evaluated for their cytotoxic activities against KB and MCF-7 cell lines. Compounds 3, 4, and 5 showed the strongest activities against both cell lines with IC50 values in the range of 0.03–0.12 μM, and compound 2 only showed a significant cytotoxicity against KB cell line (IC50 = 0.26 μM) and a moderate cytotoxicity against MCF-7 (IC50 = 10.4 μM). Compounds 1 and 6 showed weak cytotoxic activities against KB cell line with IC50 values of 29.3 and 24.7 μM, respectively. |
| format | Article |
| id | doaj-art-7ec7af4eb87d4d7d89a901fe249290f6 |
| institution | Kabale University |
| issn | 2090-8865 2090-8873 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Analytical Methods in Chemistry |
| spelling | doaj-art-7ec7af4eb87d4d7d89a901fe249290f62025-02-03T05:59:18ZengWileyJournal of Analytical Methods in Chemistry2090-88652090-88732019-01-01201910.1155/2019/29170322917032Cytotoxic Phenolic Compounds from Fruit Glandular Trichomes of Macaranga tanariusThi Mai Huong Doan0Thuy Linh Nguyen1Thi Thanh Van Trinh2Van Nam Vu3Thi Dao Phi4Marc Litaudon5Fanny Roussi6Van Minh Chau7Van Cuong Pham8Advanced Center for Bioorganic Chemistry, Institute of Marine Biochemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Caugiay, Hanoi, VietnamAdvanced Center for Bioorganic Chemistry, Institute of Marine Biochemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Caugiay, Hanoi, VietnamAdvanced Center for Bioorganic Chemistry, Institute of Marine Biochemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Caugiay, Hanoi, VietnamAdvanced Center for Bioorganic Chemistry, Institute of Marine Biochemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Caugiay, Hanoi, VietnamAdvanced Center for Bioorganic Chemistry, Institute of Marine Biochemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Caugiay, Hanoi, VietnamInstitut de Chimie des Substances Naturelles, CNRS, ICSN UPR2301, University of Paris-Saclay, 91198 Gif-sur-Yvette, FranceInstitut de Chimie des Substances Naturelles, CNRS, ICSN UPR2301, University of Paris-Saclay, 91198 Gif-sur-Yvette, FranceAdvanced Center for Bioorganic Chemistry, Institute of Marine Biochemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Caugiay, Hanoi, VietnamAdvanced Center for Bioorganic Chemistry, Institute of Marine Biochemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Caugiay, Hanoi, VietnamA new flavonoid, macatanarin D (1), together with five known stilbenes (2-6), was isolated from fruit glandular trichomes of Macaranga tanarius. Their structures were elucidated on the basis of spectroscopic methods and through comparison with data reported in the literature. All isolated compounds were evaluated for their cytotoxic activities against KB and MCF-7 cell lines. Compounds 3, 4, and 5 showed the strongest activities against both cell lines with IC50 values in the range of 0.03–0.12 μM, and compound 2 only showed a significant cytotoxicity against KB cell line (IC50 = 0.26 μM) and a moderate cytotoxicity against MCF-7 (IC50 = 10.4 μM). Compounds 1 and 6 showed weak cytotoxic activities against KB cell line with IC50 values of 29.3 and 24.7 μM, respectively.http://dx.doi.org/10.1155/2019/2917032 |
| spellingShingle | Thi Mai Huong Doan Thuy Linh Nguyen Thi Thanh Van Trinh Van Nam Vu Thi Dao Phi Marc Litaudon Fanny Roussi Van Minh Chau Van Cuong Pham Cytotoxic Phenolic Compounds from Fruit Glandular Trichomes of Macaranga tanarius Journal of Analytical Methods in Chemistry |
| title | Cytotoxic Phenolic Compounds from Fruit Glandular Trichomes of Macaranga tanarius |
| title_full | Cytotoxic Phenolic Compounds from Fruit Glandular Trichomes of Macaranga tanarius |
| title_fullStr | Cytotoxic Phenolic Compounds from Fruit Glandular Trichomes of Macaranga tanarius |
| title_full_unstemmed | Cytotoxic Phenolic Compounds from Fruit Glandular Trichomes of Macaranga tanarius |
| title_short | Cytotoxic Phenolic Compounds from Fruit Glandular Trichomes of Macaranga tanarius |
| title_sort | cytotoxic phenolic compounds from fruit glandular trichomes of macaranga tanarius |
| url | http://dx.doi.org/10.1155/2019/2917032 |
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