Evaluating [<sup>68</sup>Ga]-Ga PSMA PET/CT for Detecting Prostate Cancer Recurrence Post-High-Intensity Focused Ultrasound and Brachytherapy: A Single-Center Retrospective Study
Focal therapy offers a promising approach for treating localized prostate cancer (PC) with minimal invasiveness and potential cost benefits. High-intensity focused ultrasound (HIFU) and brachytherapy (BT) are among these options but lack long-term efficacy data. Patient follow-ups typically use biop...
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MDPI AG
2024-12-01
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| Series: | Current Oncology |
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| Online Access: | https://www.mdpi.com/1718-7729/32/1/9 |
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| author | Andrea Di Giorgio Marco Rapa Simona Civollani Andrea Farolfi Stefano Fanti |
| author_facet | Andrea Di Giorgio Marco Rapa Simona Civollani Andrea Farolfi Stefano Fanti |
| author_sort | Andrea Di Giorgio |
| collection | DOAJ |
| description | Focal therapy offers a promising approach for treating localized prostate cancer (PC) with minimal invasiveness and potential cost benefits. High-intensity focused ultrasound (HIFU) and brachytherapy (BT) are among these options but lack long-term efficacy data. Patient follow-ups typically use biopsies and multiparametric MRI (mpMRI), which often miss recurrences. PET/CT with PSMA has emerged as a promising tool for detecting residual disease or recurrence post-treatment, offering higher sensitivity and specificity than traditional imaging. We retrospectively reviewed patients who underwent [<sup>68</sup>Ga]Ga-PSMA-11 PET/CT for biochemical recurrence (BCR) after HIFU or brachytherapy from 2016 to 2024. Out of 22 patients, 32% had HIFU and 68% had brachytherapy. The median time from treatment to PET scan was 77 months, with a median PSA level of 3 ng/mL. [<sup>68</sup>Ga]Ga-PSMA-11 PET/CT identified PC recurrence in 63.6% of cases. Of these, 50% showed prostate recurrence, 14% had lymph node involvement, and 28% had metastatic disease. Focal therapies like HIFU and brachytherapy are effective and minimally invasive options for localized PC. [<sup>68</sup>Ga]Ga-PSMA-11 PET/CT is valuable for detecting recurrence or residual disease, enhancing post-treatment surveillance. |
| format | Article |
| id | doaj-art-7ec7a707ca2a49fd8cc8447c39e89f60 |
| institution | Kabale University |
| issn | 1198-0052 1718-7729 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
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| series | Current Oncology |
| spelling | doaj-art-7ec7a707ca2a49fd8cc8447c39e89f602025-01-24T13:28:20ZengMDPI AGCurrent Oncology1198-00521718-77292024-12-01321910.3390/curroncol32010009Evaluating [<sup>68</sup>Ga]-Ga PSMA PET/CT for Detecting Prostate Cancer Recurrence Post-High-Intensity Focused Ultrasound and Brachytherapy: A Single-Center Retrospective StudyAndrea Di Giorgio0Marco Rapa1Simona Civollani2Andrea Farolfi3Stefano Fanti4Nuclear Medicine, Alma Mater Studiorum, University of Bologna, Via Massarenti 9, 40138 Bologna, ItalyNuclear Medicine, Alma Mater Studiorum, University of Bologna, Via Massarenti 9, 40138 Bologna, ItalyDepartment of Medical Physics, IRCCS, Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, ItalyNuclear Medicine, IRCCS, Azienda Ospedaliero-Universitaria Di Bologna, 40138 Bologna, ItalyNuclear Medicine, Alma Mater Studiorum, University of Bologna, Via Massarenti 9, 40138 Bologna, ItalyFocal therapy offers a promising approach for treating localized prostate cancer (PC) with minimal invasiveness and potential cost benefits. High-intensity focused ultrasound (HIFU) and brachytherapy (BT) are among these options but lack long-term efficacy data. Patient follow-ups typically use biopsies and multiparametric MRI (mpMRI), which often miss recurrences. PET/CT with PSMA has emerged as a promising tool for detecting residual disease or recurrence post-treatment, offering higher sensitivity and specificity than traditional imaging. We retrospectively reviewed patients who underwent [<sup>68</sup>Ga]Ga-PSMA-11 PET/CT for biochemical recurrence (BCR) after HIFU or brachytherapy from 2016 to 2024. Out of 22 patients, 32% had HIFU and 68% had brachytherapy. The median time from treatment to PET scan was 77 months, with a median PSA level of 3 ng/mL. [<sup>68</sup>Ga]Ga-PSMA-11 PET/CT identified PC recurrence in 63.6% of cases. Of these, 50% showed prostate recurrence, 14% had lymph node involvement, and 28% had metastatic disease. Focal therapies like HIFU and brachytherapy are effective and minimally invasive options for localized PC. [<sup>68</sup>Ga]Ga-PSMA-11 PET/CT is valuable for detecting recurrence or residual disease, enhancing post-treatment surveillance.https://www.mdpi.com/1718-7729/32/1/9prostate cancerPETPSMAHIFUbrachytherapynuclear medicine |
| spellingShingle | Andrea Di Giorgio Marco Rapa Simona Civollani Andrea Farolfi Stefano Fanti Evaluating [<sup>68</sup>Ga]-Ga PSMA PET/CT for Detecting Prostate Cancer Recurrence Post-High-Intensity Focused Ultrasound and Brachytherapy: A Single-Center Retrospective Study Current Oncology prostate cancer PET PSMA HIFU brachytherapy nuclear medicine |
| title | Evaluating [<sup>68</sup>Ga]-Ga PSMA PET/CT for Detecting Prostate Cancer Recurrence Post-High-Intensity Focused Ultrasound and Brachytherapy: A Single-Center Retrospective Study |
| title_full | Evaluating [<sup>68</sup>Ga]-Ga PSMA PET/CT for Detecting Prostate Cancer Recurrence Post-High-Intensity Focused Ultrasound and Brachytherapy: A Single-Center Retrospective Study |
| title_fullStr | Evaluating [<sup>68</sup>Ga]-Ga PSMA PET/CT for Detecting Prostate Cancer Recurrence Post-High-Intensity Focused Ultrasound and Brachytherapy: A Single-Center Retrospective Study |
| title_full_unstemmed | Evaluating [<sup>68</sup>Ga]-Ga PSMA PET/CT for Detecting Prostate Cancer Recurrence Post-High-Intensity Focused Ultrasound and Brachytherapy: A Single-Center Retrospective Study |
| title_short | Evaluating [<sup>68</sup>Ga]-Ga PSMA PET/CT for Detecting Prostate Cancer Recurrence Post-High-Intensity Focused Ultrasound and Brachytherapy: A Single-Center Retrospective Study |
| title_sort | evaluating sup 68 sup ga ga psma pet ct for detecting prostate cancer recurrence post high intensity focused ultrasound and brachytherapy a single center retrospective study |
| topic | prostate cancer PET PSMA HIFU brachytherapy nuclear medicine |
| url | https://www.mdpi.com/1718-7729/32/1/9 |
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