Hyperphosphorylated tau-based Alzheimer’s Disease drug discovery: Identification of inhibitors of tau aggregation and cytotoxicity

Hyperphosphorylated tau-based Alzheimer’s Disease drug discovery: Identification of inhibitors of tau aggregation and cytotoxicity

Alzheimer’s disease (AD) is a neurodegenerative disorder that affects more than 30 million people worldwide. Underlying the progressive decline of cognitive functions are the neurofibrillary tangles (NFTs) in neurons of the brain. The spatiotemporal distribution of NFTs predicts the progression of c...

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Main Authors: Hsiao-Tien Hagar, Virneliz Fernandez-Vega, Kuang-Wei Wang, Luis M. Ortiz Jordan, Justin Shumate, Louis Scampavia, April Sweet Tapayan, Hien M Nguyen, Timothy P. Spicer, Min-Hao Kuo
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:SLAS Discovery
Subjects:
Hts
Inhibitor
Alzheimer’s disease
Amyloid
Aggregation
Fluorescence
Online Access:http://www.sciencedirect.com/science/article/pii/S2472555225000280
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