Multi-omics approach reveals the impact of prognosis model-related genes on the tumor microenvironment in medulloblastoma

Multi-omics approach reveals the impact of prognosis model-related genes on the tumor microenvironment in medulloblastoma

BackgroundThe tumor microenvironment (TME) significantly impacts the progression and prognosis of medulloblastoma (MB). This study aimed to develop a TME-associated risk score(TMErisk) model using RNA sequencing data to predict patient outcomes and elucidate biological mechanisms.MethodsRNA sequenci...

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Bibliographic Details
Main Authors: Dongming Han, Xuan Chen, Xin Jin, Jiankang Li, Dongyang Wang, Ziwei Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-03-01
Series:Frontiers in Oncology
Subjects:
tumor microenvironment (TME)
medulloblastoma (MB)
TMErisk model
single-cell RNA sequencing (scRNA-seq)
spatial transcriptomics
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2025.1477617/full
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https://www.frontiersin.org/articles/10.3389/fonc.2025.1477617/full

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