The Role of miRNAs as Biomarkers for Pregnancy Outcomes: A Comprehensive Review
Several studies showed that altered expression of the miRNA-ome in maternal circulation or in placental tissue may reflect not only gestational disorders, such as preeclampsia, spontaneous abortion, preterm birth, low birth weight, or macrosomia, but also prenatal exposure to environmental pollutant...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | International Journal of Genomics |
| Online Access: | http://dx.doi.org/10.1155/2017/8067972 |
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| _version_ | 1832556683352604672 |
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| author | Martina Barchitta Andrea Maugeri Annalisa Quattrocchi Ottavia Agrifoglio Antonella Agodi |
| author_facet | Martina Barchitta Andrea Maugeri Annalisa Quattrocchi Ottavia Agrifoglio Antonella Agodi |
| author_sort | Martina Barchitta |
| collection | DOAJ |
| description | Several studies showed that altered expression of the miRNA-ome in maternal circulation or in placental tissue may reflect not only gestational disorders, such as preeclampsia, spontaneous abortion, preterm birth, low birth weight, or macrosomia, but also prenatal exposure to environmental pollutants. Generally, the relationships between environmental exposure, changes in miRNA expression, and gestational disorders are explored separately, producing conflicting findings. However, validation of tissue-accessible biomarkers for the monitoring of adverse pregnancy outcomes needs a systematic methodological approach that takes also into account early-life environmental exposure. To achieve this goal, exposure to xenochemicals, endogenous agents, and diet should be assessed. This study has the aim to provide a comprehensive review on the role of miRNAs as potential biomarkers for adverse pregnancy outcomes and prenatal environmental exposure. |
| format | Article |
| id | doaj-art-7ea5afbe733b47a7b0e78fd0ca0bdd59 |
| institution | Kabale University |
| issn | 2314-436X 2314-4378 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Genomics |
| spelling | doaj-art-7ea5afbe733b47a7b0e78fd0ca0bdd592025-02-03T05:44:41ZengWileyInternational Journal of Genomics2314-436X2314-43782017-01-01201710.1155/2017/80679728067972The Role of miRNAs as Biomarkers for Pregnancy Outcomes: A Comprehensive ReviewMartina Barchitta0Andrea Maugeri1Annalisa Quattrocchi2Ottavia Agrifoglio3Antonella Agodi4Department of Medical and Surgical Sciences and Advanced Technologies “GF Ingrassia”, University of Catania, Catania, ItalyDepartment of Medical and Surgical Sciences and Advanced Technologies “GF Ingrassia”, University of Catania, Catania, ItalyDepartment of Medical and Surgical Sciences and Advanced Technologies “GF Ingrassia”, University of Catania, Catania, ItalyDepartment of Medical and Surgical Sciences and Advanced Technologies “GF Ingrassia”, University of Catania, Catania, ItalyDepartment of Medical and Surgical Sciences and Advanced Technologies “GF Ingrassia”, University of Catania, Catania, ItalySeveral studies showed that altered expression of the miRNA-ome in maternal circulation or in placental tissue may reflect not only gestational disorders, such as preeclampsia, spontaneous abortion, preterm birth, low birth weight, or macrosomia, but also prenatal exposure to environmental pollutants. Generally, the relationships between environmental exposure, changes in miRNA expression, and gestational disorders are explored separately, producing conflicting findings. However, validation of tissue-accessible biomarkers for the monitoring of adverse pregnancy outcomes needs a systematic methodological approach that takes also into account early-life environmental exposure. To achieve this goal, exposure to xenochemicals, endogenous agents, and diet should be assessed. This study has the aim to provide a comprehensive review on the role of miRNAs as potential biomarkers for adverse pregnancy outcomes and prenatal environmental exposure.http://dx.doi.org/10.1155/2017/8067972 |
| spellingShingle | Martina Barchitta Andrea Maugeri Annalisa Quattrocchi Ottavia Agrifoglio Antonella Agodi The Role of miRNAs as Biomarkers for Pregnancy Outcomes: A Comprehensive Review International Journal of Genomics |
| title | The Role of miRNAs as Biomarkers for Pregnancy Outcomes: A Comprehensive Review |
| title_full | The Role of miRNAs as Biomarkers for Pregnancy Outcomes: A Comprehensive Review |
| title_fullStr | The Role of miRNAs as Biomarkers for Pregnancy Outcomes: A Comprehensive Review |
| title_full_unstemmed | The Role of miRNAs as Biomarkers for Pregnancy Outcomes: A Comprehensive Review |
| title_short | The Role of miRNAs as Biomarkers for Pregnancy Outcomes: A Comprehensive Review |
| title_sort | role of mirnas as biomarkers for pregnancy outcomes a comprehensive review |
| url | http://dx.doi.org/10.1155/2017/8067972 |
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