Precise Engineering and Efficient Biosynthesis of Robust and High‐Activity Human Haemoglobin for Artificial Oxygen Carriers

Precise Engineering and Efficient Biosynthesis of Robust and High‐Activity Human Haemoglobin for Artificial Oxygen Carriers

ABSTRACT Recombinant human haemoglobin (rHb) is a tetramer protein with heme as cofactors, which have extensive applications in the fields of biomaterials and biomedical therapeutics. However, due to the poor structural stability, the dissociation of heme, weak oxygen transport efficiency, and lower...

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Bibliographic Details
Main Authors: Fan Liu, Jingwen Zhou, Jianghua Li, Jian Chen, Guocheng Du, Xinrui Zhao
Format: Article
Language:English
Published: Wiley 2025-03-01
Series:Microbial Biotechnology
Subjects:
heme loss
heme‐supply
high‐activity
oxygen transport efficiency
recombinant human haemoglobin
structural stability
Online Access:https://doi.org/10.1111/1751-7915.70128
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https://doi.org/10.1111/1751-7915.70128

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