Formulation Study of a Poly(amino methacrylate) Film-Forming Solution for Transdermal Administration
Background/Objectives: The objective of this paper is to design a novel film-forming system (FFS) based on Eudragit<sup>®</sup> E PO (EuE) polymeric solutions, differing in volatile solvents (i.e., isopropanol and ethanol) and plasticizers (i.e., tributylcitrate, glycerine, triacetin and...
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2025-01-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/17/1/88 |
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| author | Chiara G. M. Gennari Antonella Casiraghi Francesca Selmin Francesco Cilurzo |
| author_facet | Chiara G. M. Gennari Antonella Casiraghi Francesca Selmin Francesco Cilurzo |
| author_sort | Chiara G. M. Gennari |
| collection | DOAJ |
| description | Background/Objectives: The objective of this paper is to design a novel film-forming system (FFS) based on Eudragit<sup>®</sup> E PO (EuE) polymeric solutions, differing in volatile solvents (i.e., isopropanol and ethanol) and plasticizers (i.e., tributylcitrate, glycerine, triacetin and PEG 400). Methods: The physicochemical and mechanical properties of the FFS and dried films were evaluated in terms of formation time, stickiness, T<sub>g</sub>, tensile strength, break elongation and Young’s modulus. The in vitro skin permeation studies were conducted on formulations containing caffeine and testosterone. Results: The FFS, consisting of EuE and PEG400 in isopropyl alcohol and ethanol (80:20, <i>v</i>/<i>v</i>), exhibited rapid film formation within about 5 min and the dried film allowed a high skin permeability compared to other formulations due to the ability to increase the thermodynamic activity of both drugs. When triiodothyronine (T3) was loaded as a model of a very low soluble drug, tocopherol polyethylene glycol succinate (TPGS) was added as a co-solvent and it allowed for the improvement of T3 retention in the skin. Conclusions: Among the formulative variables, the nature and the amount of plasticizer represent the most critical variables to obtain an EuE-based film with satisfying physical and biopharmaceutical properties. |
| format | Article |
| id | doaj-art-7e7629643b6b4b42b88e349b54cc9f05 |
| institution | Kabale University |
| issn | 1999-4923 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj-art-7e7629643b6b4b42b88e349b54cc9f052025-01-24T13:45:54ZengMDPI AGPharmaceutics1999-49232025-01-011718810.3390/pharmaceutics17010088Formulation Study of a Poly(amino methacrylate) Film-Forming Solution for Transdermal AdministrationChiara G. M. Gennari0Antonella Casiraghi1Francesca Selmin2Francesco Cilurzo3Department of Pharmaceutical Sciences, Università degli Studi di Milano, via G: Colombo, 71, 20133 Milano, ItalyDepartment of Pharmaceutical Sciences, Università degli Studi di Milano, via G: Colombo, 71, 20133 Milano, ItalyDepartment of Pharmaceutical Sciences, Università degli Studi di Milano, via G: Colombo, 71, 20133 Milano, ItalyDepartment of Pharmaceutical Sciences, Università degli Studi di Milano, via G: Colombo, 71, 20133 Milano, ItalyBackground/Objectives: The objective of this paper is to design a novel film-forming system (FFS) based on Eudragit<sup>®</sup> E PO (EuE) polymeric solutions, differing in volatile solvents (i.e., isopropanol and ethanol) and plasticizers (i.e., tributylcitrate, glycerine, triacetin and PEG 400). Methods: The physicochemical and mechanical properties of the FFS and dried films were evaluated in terms of formation time, stickiness, T<sub>g</sub>, tensile strength, break elongation and Young’s modulus. The in vitro skin permeation studies were conducted on formulations containing caffeine and testosterone. Results: The FFS, consisting of EuE and PEG400 in isopropyl alcohol and ethanol (80:20, <i>v</i>/<i>v</i>), exhibited rapid film formation within about 5 min and the dried film allowed a high skin permeability compared to other formulations due to the ability to increase the thermodynamic activity of both drugs. When triiodothyronine (T3) was loaded as a model of a very low soluble drug, tocopherol polyethylene glycol succinate (TPGS) was added as a co-solvent and it allowed for the improvement of T3 retention in the skin. Conclusions: Among the formulative variables, the nature and the amount of plasticizer represent the most critical variables to obtain an EuE-based film with satisfying physical and biopharmaceutical properties.https://www.mdpi.com/1999-4923/17/1/88drug delivery systemEudragit<sup>®</sup> Efilm-forming solutionplasticizerskin permeabilitysupersaturation |
| spellingShingle | Chiara G. M. Gennari Antonella Casiraghi Francesca Selmin Francesco Cilurzo Formulation Study of a Poly(amino methacrylate) Film-Forming Solution for Transdermal Administration Pharmaceutics drug delivery system Eudragit<sup>®</sup> E film-forming solution plasticizer skin permeability supersaturation |
| title | Formulation Study of a Poly(amino methacrylate) Film-Forming Solution for Transdermal Administration |
| title_full | Formulation Study of a Poly(amino methacrylate) Film-Forming Solution for Transdermal Administration |
| title_fullStr | Formulation Study of a Poly(amino methacrylate) Film-Forming Solution for Transdermal Administration |
| title_full_unstemmed | Formulation Study of a Poly(amino methacrylate) Film-Forming Solution for Transdermal Administration |
| title_short | Formulation Study of a Poly(amino methacrylate) Film-Forming Solution for Transdermal Administration |
| title_sort | formulation study of a poly amino methacrylate film forming solution for transdermal administration |
| topic | drug delivery system Eudragit<sup>®</sup> E film-forming solution plasticizer skin permeability supersaturation |
| url | https://www.mdpi.com/1999-4923/17/1/88 |
| work_keys_str_mv | AT chiaragmgennari formulationstudyofapolyaminomethacrylatefilmformingsolutionfortransdermaladministration AT antonellacasiraghi formulationstudyofapolyaminomethacrylatefilmformingsolutionfortransdermaladministration AT francescaselmin formulationstudyofapolyaminomethacrylatefilmformingsolutionfortransdermaladministration AT francescocilurzo formulationstudyofapolyaminomethacrylatefilmformingsolutionfortransdermaladministration |