TWIST1 regulates HK2 ubiquitination degradation to promote pancreatic cancer invasion and metastasis

TWIST1 regulates HK2 ubiquitination degradation to promote pancreatic cancer invasion and metastasis

Abstract Objective TWIST1 is known to promote glycolysis and contribute to pancreatic cancer development; however, its underlying mechanisms remain poorly understood. This study aims to elucidate the molecular mechanisms by which TWIST1 influences aerobic glycolysis in pancreatic ductal adenocarcino...

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Bibliographic Details
Main Authors: Xinxing Wang, Mingze Ma, Shuai Shao, Xianwen Xu, Chuan Qin, Ruxin Gao, Zhenhai Zhang
Format: Article
Language:English
Published: BMC 2025-02-01
Series:Cancer Cell International
Subjects:
Pancreatic cancer
TWIST1
HK2
Reprogrammed glucose metabolism
Ubiquitination
Online Access:https://doi.org/10.1186/s12935-024-03583-z
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