Novel alloxazine analogues: design, synthesis, and antitumour efficacy enhanced by kinase screening, molecular docking, and ADME studies

This study describes the development of novel alloxazine analogues as potent antitumor agents with enhanced selectivity for tumour cells. Twenty-nine out of 45 newly compounds were investigated in vitro for their growth inhibitory activities, against two human tumour cell lines, namely, the human T-...

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Bibliographic Details
Main Authors: Doaa Samaha, Sawsan Mahmoud, Mosaad Sayed Mohamed, Rokaia S. Abdullah, Nageh A. Abou Taleb, Tomohisa Nagamatsu, Hamed I. Ali
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:Journal of Enzyme Inhibition and Medicinal Chemistry
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Online Access:https://www.tandfonline.com/doi/10.1080/14756366.2024.2398551
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