Topobexin targets the Topoisomerase II ATPase domain for beta isoform-selective inhibition and anthracycline cardioprotection

Topobexin targets the Topoisomerase II ATPase domain for beta isoform-selective inhibition and anthracycline cardioprotection

Abstract Topoisomerase II alpha and beta (TOP2A and TOP2B) isoenzymes perform essential and non-redundant cellular functions. Anthracyclines induce their potent anti-cancer effects primarily via TOP2A, but at the same time they induce a dose limiting cardiotoxicity through TOP2B. Here we describe th...

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Main Authors: Jan Kubeš, Galina Karabanovich, Anh T. Q. Cong, Iuliia Melnikova, Olga Lenčová, Petra Kollárová, Hana Bavlovič Piskáčková, Veronika Keresteš, Lenka Applová, Lise C. M. Arrouye, Julia R. Alvey, Jasmina Paluncic, Taylor L. Witter, Anna Jirkovská, Jiří Kuneš, Petra Štěrbová-Kovaříková, Caroline A. Austin, Martin Štěrba, Tomáš Šimůnek, Jaroslav Roh, Matthew J. Schellenberg
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-60167-9
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https://doi.org/10.1038/s41467-025-60167-9

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