Sinensetin serves as an AMPK activator to inhibit RANKL-induced osteoclastogenesis via osteoclast cytoskeleton reorganization

Sinensetin serves as an AMPK activator to inhibit RANKL-induced osteoclastogenesis via osteoclast cytoskeleton reorganization

Abstract Osteoporosis is a skeletal condition caused by an excess of osteoclasts, resulting in an imbalance in bone metabolism. Sinensetin (SIN), one of the main ingredients in citrus fruits, provides a variety of pharmacological properties, like antioxidant, but its effects on osteoporosis remains...

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Main Authors: Yijie Gao, Rui Zhou, Xixi Lin, Zhijuan Liu, Yuangang Su, Haoyu Lian, Bin Lin, Xiaofei Ding, Shijie Liao, Xiangde Li, Jinmin Zhao, Jiake Xu, Ren Xu, Qian Liu, Fangming Song
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Journal of Translational Medicine
Subjects:
Osteoclast
AMPK
Cytoskeleton reorganization
ROS
Sinensetin
Online Access:https://doi.org/10.1186/s12967-025-06708-8
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https://doi.org/10.1186/s12967-025-06708-8

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