Genetic, Functional, and Immunological Study of ZnT8 in Diabetes
Zinc level in the body is finely regulated to maintain cellular function. Dysregulation of zinc metabolism may induce a variety of diseases, e.g., diabetes. Zinc participates in insulin synthesis, storage, and secretion by functioning as a “cellular second messenger” in the insulin signaling pathway...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2019/1524905 |
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| author | Qiong Huang Jie Du Chengfeng Merriman Zhicheng Gong |
| author_facet | Qiong Huang Jie Du Chengfeng Merriman Zhicheng Gong |
| author_sort | Qiong Huang |
| collection | DOAJ |
| description | Zinc level in the body is finely regulated to maintain cellular function. Dysregulation of zinc metabolism may induce a variety of diseases, e.g., diabetes. Zinc participates in insulin synthesis, storage, and secretion by functioning as a “cellular second messenger” in the insulin signaling pathway and glucose homeostasis. The highest zinc concentration is in the pancreas islets. Zinc accumulation in cell granules is manipulated by ZnT8, a zinc transporter expressed predominately in pancreatic α and β cells. A common ZnT8 gene (SLC30A8) polymorphism increases the risk of type 2 diabetes mellitus (T2DM), and rare mutations may present protective effects. In type 1 diabetes mellitus (T1DM), autoantibodies show specificity for binding two variants of ZnT8 (R or W at amino acid 325) dictated by a polymorphism in SLC30A8. In this review, we summarize the structure, feature, functions, and polymorphisms of ZnT8 along with its association with diabetes and explore future study directions. |
| format | Article |
| id | doaj-art-7e2b2f50f7c74ff1acf5e21c0f2a61b7 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-7e2b2f50f7c74ff1acf5e21c0f2a61b72025-02-03T01:01:59ZengWileyInternational Journal of Endocrinology1687-83371687-83452019-01-01201910.1155/2019/15249051524905Genetic, Functional, and Immunological Study of ZnT8 in DiabetesQiong Huang0Jie Du1Chengfeng Merriman2Zhicheng Gong3Department of Pharmacy, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha 410008, Hunan, ChinaDepartment of Pharmacy, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha 410008, Hunan, ChinaDepartment of Physiology, Johns Hopkins School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USADepartment of Pharmacy, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha 410008, Hunan, ChinaZinc level in the body is finely regulated to maintain cellular function. Dysregulation of zinc metabolism may induce a variety of diseases, e.g., diabetes. Zinc participates in insulin synthesis, storage, and secretion by functioning as a “cellular second messenger” in the insulin signaling pathway and glucose homeostasis. The highest zinc concentration is in the pancreas islets. Zinc accumulation in cell granules is manipulated by ZnT8, a zinc transporter expressed predominately in pancreatic α and β cells. A common ZnT8 gene (SLC30A8) polymorphism increases the risk of type 2 diabetes mellitus (T2DM), and rare mutations may present protective effects. In type 1 diabetes mellitus (T1DM), autoantibodies show specificity for binding two variants of ZnT8 (R or W at amino acid 325) dictated by a polymorphism in SLC30A8. In this review, we summarize the structure, feature, functions, and polymorphisms of ZnT8 along with its association with diabetes and explore future study directions.http://dx.doi.org/10.1155/2019/1524905 |
| spellingShingle | Qiong Huang Jie Du Chengfeng Merriman Zhicheng Gong Genetic, Functional, and Immunological Study of ZnT8 in Diabetes International Journal of Endocrinology |
| title | Genetic, Functional, and Immunological Study of ZnT8 in Diabetes |
| title_full | Genetic, Functional, and Immunological Study of ZnT8 in Diabetes |
| title_fullStr | Genetic, Functional, and Immunological Study of ZnT8 in Diabetes |
| title_full_unstemmed | Genetic, Functional, and Immunological Study of ZnT8 in Diabetes |
| title_short | Genetic, Functional, and Immunological Study of ZnT8 in Diabetes |
| title_sort | genetic functional and immunological study of znt8 in diabetes |
| url | http://dx.doi.org/10.1155/2019/1524905 |
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