Regulatory orchestration of FK506 biosynthesis in Streptomyces tsukubaensis NRRL 18488 revealed through systematic analysis

Regulatory orchestration of FK506 biosynthesis in Streptomyces tsukubaensis NRRL 18488 revealed through systematic analysis

Summary: Streptomyces tsukubaensis NRRL 18488, the primary producer of the immunosuppressant FK506, was analyzed to elucidate regulatory features of secondary metabolism. Completion of its 7.9-Mb linear genome enabled accurate re-annotation of the FK506 biosynthetic gene cluster (BGC). Transcriptome...

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Main Authors: Namil Lee, Woori Kim, Ji Hun Kim, Yongjae Lee, Soonkyu Hwang, Gahyeon Kim, Hyeseong Kim, Qingyun Dan, Matthias Schmidt, Yeo Joon Yoon, Suhyung Cho, Bernhard Palsson, Jay D. Keasling, Byung-Kwan Cho
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:iScience
Subjects:
Microbial genomics
Microbial metabolism
Systems biology
genomics
Transcriptomics
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004225009599
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