Co-regulation and synteny of GFM2 and NSA2 links ribosomal function in mitochondria and the cytosol with chronic kidney disease

Co-regulation and synteny of GFM2 and NSA2 links ribosomal function in mitochondria and the cytosol with chronic kidney disease

Abstract Background We previously reported aberrant expression of the cytosolic ribosomal biogenesis factor Nop-7-associated 2 (NSA2) in diabetic nephropathy, the latter also known to involve mitochondrial dysfunction, however the connections between NSA2, mitochondria and renal disease were unclear...

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Bibliographic Details
Main Authors: Minjie Zhang, Christer Hogstrand, Paola Pontrelli, Afshan N Malik
Format: Article
Language:English
Published: BMC 2024-10-01
Series:Molecular Medicine
Subjects:
NSA2
Ribosome biogenesis
Protein synthesis
Mitochondria
Gene expression, diabetic nephropathy, chronic kidney disease, mitochondrial dysfunction
Online Access:https://doi.org/10.1186/s10020-024-00930-8
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https://doi.org/10.1186/s10020-024-00930-8

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