Study on γδT-Cell Degranulation at Maternal–Fetal Interface via iKIR–HLA-C Axis

Study on γδT-Cell Degranulation at Maternal–Fetal Interface via iKIR–HLA-C Axis

Maternal–fetal tolerance mechanisms are crucial during human pregnancy to prevent the immune rejection of the embryo. A well-known mechanism blocking NK-cell cytotoxicity is the interaction of their inhibitory killer-cell immunoglobulin-like receptors (iKIR) with HLA-C molecules on the target cells....

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Bibliographic Details
Main Authors: Diana Manchorova, Marina Alexandrova, Antonia Terzieva, Ivaylo Vangelov, Ljubomir Djerov, Iana Hristova, Gil Mor, Tanya Dimova
Format: Article
Language:English
Published: MDPI AG 2025-04-01
Series:Cells
Subjects:
human pregnancy
γδT cells
inhibitory KIRs
HLA-C
degranulation
Online Access:https://www.mdpi.com/2073-4409/14/9/649
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