Xenogeneic-free culture of human intestinal stem cells on functional polymer-coated substrates for scalable, clinical-grade stem cell therapy

Xenogeneic-free culture of human intestinal stem cells on functional polymer-coated substrates for scalable, clinical-grade stem cell therapy

Abstract The need for basement membrane extract (BME) with undefined constituents, such as Matrigel, for intestinal stem cell (ISC) culture in traditional systems poses a significant barrier that must be overcome for the development of clinical-grade, scalable, ready-to-use ISCs. Here, we propose a...

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Main Authors: Seonghyeon Park, Ohman Kwon, Hana Lee, Younghak Cho, Jemin Yeun, Sung Hyun Yoon, Sang Yu Sun, Yubin Huh, Won Dong Yu, Sohee Park, Naeun Son, Sojeong Jeon, Sugi Lee, Dae-Soo Kim, Sun Young Lee, Jin Gyeong Son, Kyung Jin Lee, Yong Il Kim, Jin Hong Lim, Jongman Yoo, Tae Geol Lee, Mi-Young Son, Sung Gap Im
Format: Article
Language:English
Published: Nature Portfolio 2024-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-54653-9
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https://doi.org/10.1038/s41467-024-54653-9

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