Neuroimaging Findings of Psychosis in Alzheimer's Disease: A Systematic Review
ABSTRACT Background Previous studies on neuroimaging findings in Alzheimer's disease (AD) patients with hallucinations and delusions have yielded inconsistent results. We aimed to systematically review neuroimaging findings of delusions and hallucinations in AD patients to describe the most pro...
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| Format: | Article |
| Language: | English |
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Wiley
2025-01-01
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| Series: | Brain and Behavior |
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| Online Access: | https://doi.org/10.1002/brb3.70205 |
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| author | Fardin Nabizadeh Shadi Sheykhlou Sara Mahmoodi Elham Khalili Rasa Zafari Helia Hosseini |
| author_facet | Fardin Nabizadeh Shadi Sheykhlou Sara Mahmoodi Elham Khalili Rasa Zafari Helia Hosseini |
| author_sort | Fardin Nabizadeh |
| collection | DOAJ |
| description | ABSTRACT Background Previous studies on neuroimaging findings in Alzheimer's disease (AD) patients with hallucinations and delusions have yielded inconsistent results. We aimed to systematically review neuroimaging findings of delusions and hallucinations in AD patients to describe the most prominent neuroimaging features. Methods We performed a comprehensive search in three online databases, including PubMed, Scopus, and Web of Science in June 2023. We included studies that reported neuroimaging features of AD patients with delusion, hallucination, or psychosis. Results After the screening, 34 studies with 2241 AD patients were eligible to be included in our qualitative synthesis. On the basis of the included studies, there are significant changes in the volume and perfusion levels of broad brain areas, including the hippocampus, amygdala, insula, cingulate, occipital, frontal, prefrontal, orbitofrontal, temporal, and parietal cortices in these patients. Moreover, AD patients with psychosis, hallucinations, or delusions reflected different EEG waves compared to AD patients without these disorders. Conclusion The results of our review provided evidence about the neuroimaging alterations in AD patients suffering from psychosis, hallucinations, and delusions using different imaging methods. AD patients with psychosis, hallucinations, or delusions have significant differences in the volume and perfusion levels of various brain regions along with alterations in EEG waves and biological molecules compared to patients with only AD. |
| format | Article |
| id | doaj-art-7dff26f60fea4aa097a07f6c141aa4fc |
| institution | Kabale University |
| issn | 2162-3279 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Brain and Behavior |
| spelling | doaj-art-7dff26f60fea4aa097a07f6c141aa4fc2025-01-29T13:36:39ZengWileyBrain and Behavior2162-32792025-01-01151n/an/a10.1002/brb3.70205Neuroimaging Findings of Psychosis in Alzheimer's Disease: A Systematic ReviewFardin Nabizadeh0Shadi Sheykhlou1Sara Mahmoodi2Elham Khalili3Rasa Zafari4Helia Hosseini5School of Medicine Iran University of Medical Sciences Tehran IranMedical Laboratory Department Iran University of Medical Sciences Tehran IranMedical Laboratory Department Iran University of Medical Sciences Tehran IranUniversal Scientific Education and Research Network (USERN) Bandar Abbas Hormozgan IranSchool of Medicine Tehran University of Medical Science Tehran IranFaculty of Medicine Tehran University of Medical Sciences Tehran IranABSTRACT Background Previous studies on neuroimaging findings in Alzheimer's disease (AD) patients with hallucinations and delusions have yielded inconsistent results. We aimed to systematically review neuroimaging findings of delusions and hallucinations in AD patients to describe the most prominent neuroimaging features. Methods We performed a comprehensive search in three online databases, including PubMed, Scopus, and Web of Science in June 2023. We included studies that reported neuroimaging features of AD patients with delusion, hallucination, or psychosis. Results After the screening, 34 studies with 2241 AD patients were eligible to be included in our qualitative synthesis. On the basis of the included studies, there are significant changes in the volume and perfusion levels of broad brain areas, including the hippocampus, amygdala, insula, cingulate, occipital, frontal, prefrontal, orbitofrontal, temporal, and parietal cortices in these patients. Moreover, AD patients with psychosis, hallucinations, or delusions reflected different EEG waves compared to AD patients without these disorders. Conclusion The results of our review provided evidence about the neuroimaging alterations in AD patients suffering from psychosis, hallucinations, and delusions using different imaging methods. AD patients with psychosis, hallucinations, or delusions have significant differences in the volume and perfusion levels of various brain regions along with alterations in EEG waves and biological molecules compared to patients with only AD.https://doi.org/10.1002/brb3.70205Alzheimer's diseasedelusionhallucinationneuroimagingpsychosis |
| spellingShingle | Fardin Nabizadeh Shadi Sheykhlou Sara Mahmoodi Elham Khalili Rasa Zafari Helia Hosseini Neuroimaging Findings of Psychosis in Alzheimer's Disease: A Systematic Review Brain and Behavior Alzheimer's disease delusion hallucination neuroimaging psychosis |
| title | Neuroimaging Findings of Psychosis in Alzheimer's Disease: A Systematic Review |
| title_full | Neuroimaging Findings of Psychosis in Alzheimer's Disease: A Systematic Review |
| title_fullStr | Neuroimaging Findings of Psychosis in Alzheimer's Disease: A Systematic Review |
| title_full_unstemmed | Neuroimaging Findings of Psychosis in Alzheimer's Disease: A Systematic Review |
| title_short | Neuroimaging Findings of Psychosis in Alzheimer's Disease: A Systematic Review |
| title_sort | neuroimaging findings of psychosis in alzheimer s disease a systematic review |
| topic | Alzheimer's disease delusion hallucination neuroimaging psychosis |
| url | https://doi.org/10.1002/brb3.70205 |
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