Microneedle-based sustained release delivery of TNF-α/IL-6R dual-specific fenobody alleviates inflammation and promotes bone regeneration in rheumatoid arthritis rat model

Microneedle-based sustained release delivery of TNF-α/IL-6R dual-specific fenobody alleviates inflammation and promotes bone regeneration in rheumatoid arthritis rat model

Rheumatoid arthritis (RA) is a chronic, systemic autoimmune disease characterized by inflammatory imbalance. The cytokine-targeted therapy is a non-traditional form of RA treatment that is mighty effective but poses the challenge of pharmaceutical storage conditions, professional injection, frequent...

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Bibliographic Details
Main Authors: Xiqian Zhang, Jian Chen, Na Huang, Qi Chen, Muhammad Asad Farooq, Ping Ouyang, Kaisong Huang, Kangsheng Liao, Wanjun He, Kai Cui, Dan Jiang, Guangxian Xu
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:Materials Today Bio
Subjects:
Rheumatoid arthritis
TNF-α
IL-6R
Fenobody
GelMA microneedle
Online Access:http://www.sciencedirect.com/science/article/pii/S2590006425004752
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