A single-cell transcriptome analysis reveals astrocyte heterogeneity and identifies CHI3L1 as a diagnostic biomarker in Parkinson's disease

A single-cell transcriptome analysis reveals astrocyte heterogeneity and identifies CHI3L1 as a diagnostic biomarker in Parkinson's disease

Background: Parkinson's disease (PD) is the second most common neurodegenerative disease, characterized by motor and non-motor symptoms. It has been reported that astrocytes play a critical role in the pathogenesis and progression of PD. Here, we aimed to identify the heterogeneity of astrocyte...

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Bibliographic Details
Main Authors: Zhongying Gong, Dan Guo, Yufeng Lin, Zhiwei Liu, Mengdi Lv, Xinxin Liu, Yang Yao, Sijia Wang, Yuan Wang, Zhiyun Wang
Format: Article
Language:English
Published: Elsevier 2025-02-01
Series:Heliyon
Subjects:
Parkinson's disease
Astrocytes
CHI3L1
Inflammation
Diagnostic biomarker
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844025004311
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