Huntingtin inclusion bodies have distinct immunophenotypes and ubiquitination profiles in the Huntington’s disease human cerebral cortex

Huntingtin inclusion bodies have distinct immunophenotypes and ubiquitination profiles in the Huntington’s disease human cerebral cortex

Abstract Huntington’s disease (HD) is a hereditary neurodegenerative condition caused by a CAG repeat expansion mutation in the gene encoding the huntingtin (HTT) protein. The accumulation of HTT inclusion bodies is a pathological hallmark of HD and a common target for therapeutic strategies. Howeve...

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Main Authors: Molly E. V. Swanson, Adelie Y. S. Tan, Lynette J. Tippett, Clinton P. Turner, Maurice A. Curtis, Emma L. Scotter, Hilal A. Lashuel, Mike Dragunow, Richard L. M. Faull, Helen C. Murray, Malvindar K. Singh-Bains
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-025-00465-w
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https://doi.org/10.1038/s41598-025-00465-w

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