Acupuncture regulates astrocyte neurotoxic polarization to protect blood–brain barrier integrity in delayed thrombolysis through mediating ERK1/2/Cx43 axis

Background: Thrombolytic therapy remains the standard treatment for acute ischemic stroke. The narrow window for thrombolysis means that delay in treatment worsens brain injury. Astrocytes regulate blood-brain barrier (BBB) integrity and neuroinflammation, yet their neurotoxic polarization exacerbat...

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Bibliographic Details
Main Authors: Zhi-Hui Zhang, Yu Gu, Zheng Huang, Xin-Yu Liu, Wen-Tao Xu, Xin-Chang Zhang, Guang-Xia Ni
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:IBRO Neuroscience Reports
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Online Access:http://www.sciencedirect.com/science/article/pii/S2667242125000533
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