The Potential Role of Gut Microbiota in the Prevention and Treatment of Lipid Metabolism Disorders
Due to changes in lifestyle, diet structure, and aging worldwide, the incidence of metabolic syndromes such as hyperlipidemia, hypertension, diabetes, and obesity is increasing. Metabolic syndrome is considered to be closely related to cardiovascular disease and severely affects human health. In rec...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2020/8601796 |
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| author | Yan-Jun He Chong-Ge You |
| author_facet | Yan-Jun He Chong-Ge You |
| author_sort | Yan-Jun He |
| collection | DOAJ |
| description | Due to changes in lifestyle, diet structure, and aging worldwide, the incidence of metabolic syndromes such as hyperlipidemia, hypertension, diabetes, and obesity is increasing. Metabolic syndrome is considered to be closely related to cardiovascular disease and severely affects human health. In recent years, researchers have revealed that the gut microbiota, through its own or interacting metabolites, has a positive role in regulating metabolic syndrome. Therefore, the gut microbiota has been a new “organ” for the treatment of metabolic syndrome. The role has not been clarified, and more research is necessary to prove the specific role of specific strains. Probiotics are also believed to regulate metabolic syndromes by regulating the gut microbiota and are expected to become a new preparation for treating metabolic syndromes. This review focuses on the regulation of lipid metabolism disorders by the gut microbiota through the effects of bile acids (BA), short-chain fatty acids (SCFAs), bile salt hydrolase (BSH), and genes such as ABCG5 and ABCG8, FXR, NPC1L, and LDL-R. |
| format | Article |
| id | doaj-art-7dbb9c468ea64ad3af25e3dda0def995 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-7dbb9c468ea64ad3af25e3dda0def9952025-02-03T06:46:41ZengWileyInternational Journal of Endocrinology1687-83371687-83452020-01-01202010.1155/2020/86017968601796The Potential Role of Gut Microbiota in the Prevention and Treatment of Lipid Metabolism DisordersYan-Jun He0Chong-Ge You1Laboratory Medicine Center, Lanzhou University Second Hospital, No. 82 Cuiyingmen Lanzhou, Lanzhou 730030, Gansu, ChinaLaboratory Medicine Center, Lanzhou University Second Hospital, No. 82 Cuiyingmen Lanzhou, Lanzhou 730030, Gansu, ChinaDue to changes in lifestyle, diet structure, and aging worldwide, the incidence of metabolic syndromes such as hyperlipidemia, hypertension, diabetes, and obesity is increasing. Metabolic syndrome is considered to be closely related to cardiovascular disease and severely affects human health. In recent years, researchers have revealed that the gut microbiota, through its own or interacting metabolites, has a positive role in regulating metabolic syndrome. Therefore, the gut microbiota has been a new “organ” for the treatment of metabolic syndrome. The role has not been clarified, and more research is necessary to prove the specific role of specific strains. Probiotics are also believed to regulate metabolic syndromes by regulating the gut microbiota and are expected to become a new preparation for treating metabolic syndromes. This review focuses on the regulation of lipid metabolism disorders by the gut microbiota through the effects of bile acids (BA), short-chain fatty acids (SCFAs), bile salt hydrolase (BSH), and genes such as ABCG5 and ABCG8, FXR, NPC1L, and LDL-R.http://dx.doi.org/10.1155/2020/8601796 |
| spellingShingle | Yan-Jun He Chong-Ge You The Potential Role of Gut Microbiota in the Prevention and Treatment of Lipid Metabolism Disorders International Journal of Endocrinology |
| title | The Potential Role of Gut Microbiota in the Prevention and Treatment of Lipid Metabolism Disorders |
| title_full | The Potential Role of Gut Microbiota in the Prevention and Treatment of Lipid Metabolism Disorders |
| title_fullStr | The Potential Role of Gut Microbiota in the Prevention and Treatment of Lipid Metabolism Disorders |
| title_full_unstemmed | The Potential Role of Gut Microbiota in the Prevention and Treatment of Lipid Metabolism Disorders |
| title_short | The Potential Role of Gut Microbiota in the Prevention and Treatment of Lipid Metabolism Disorders |
| title_sort | potential role of gut microbiota in the prevention and treatment of lipid metabolism disorders |
| url | http://dx.doi.org/10.1155/2020/8601796 |
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