Type I-E* CRISPR-Cas of Klebsiella pneumoniae upregulates bacterial virulence by targeting endogenous histidine utilization system

Type I-E* CRISPR-Cas of Klebsiella pneumoniae upregulates bacterial virulence by targeting endogenous histidine utilization system

ABSTRACT Klebsiella pneumoniae is a globally recognized microbial pathogen with significant clinical impact. The bacterium harbors the clustered regularly interspaced short palindromic repeats (CRISPR)-Cas systems, which provide adaptive immunity against invading foreign nucleic acids. Recent studie...

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Main Authors: Jieying Li, Yuxiao Liu, Jingsi Jiang, Fang Chen, Nan Zhang, Xun Kang, Lin Liu, Yingjuan Wang, Qianfeng Xia, Chuanlong Zhu, Dai Kuang
Format: Article
Language:English
Published: American Society for Microbiology 2025-06-01
Series:mSphere
Subjects:
CRISPR-Cas system
Klebsiella pneumoniae
virulence
self-targeting regulation
histidine utilization
Online Access:https://journals.asm.org/doi/10.1128/msphere.00215-25
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