Extreme temperatures modulate gene expression in the airway epithelium of the lungs in mice and asthma patients

Extreme temperatures modulate gene expression in the airway epithelium of the lungs in mice and asthma patients

BackgroundThe objective of this study was to examine the effects of extreme temperatures on the gene signature and pathways of airway epithelial cells in mice and asthma patients.MethodsWe investigated the effects of temperature exposure at normal (22°C), and extreme low (10°C), high (40°C) and temp...

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Main Authors: Firdian Makrufardi, Syue-Wei Peng, Kian Fan Chung, Marc Chadeau-Hyam, Kang-Yun Lee, Ta-Chih Hsiao, Kin-Fai Ho, Desy Rusmawatiningtyas, Indah Kartika Murni, Eggi Arguni, Yuan-Hung Wang, Shu-Chuan Ho, Feng-Ming Yang, Kai-Jen Chuang, Sheng-Chieh Lin, Hsiao-Chi Chuang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Medicine
Subjects:
airway epithelium
climate change
extreme weather
lung
thermal
Online Access:https://www.frontiersin.org/articles/10.3389/fmed.2025.1531154/full
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https://www.frontiersin.org/articles/10.3389/fmed.2025.1531154/full

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