Mechanisms and Therapeutic Strategies of Macrophage Polarization in Intervertebral Disc Degeneration

Mechanisms and Therapeutic Strategies of Macrophage Polarization in Intervertebral Disc Degeneration

ABSTRACT Background Intervertebral disc degeneration (IVDD) is a leading cause of low back pain (LBP), contributing significantly to global disability and productivity loss. Its pathogenesis involves complex processes, including inflammation, cellular senescence, angiogenesis, fibrosis, neural ingro...

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Bibliographic Details
Main Authors: Kaiyuan Zheng, Siyu Wang, Meng Deng, Yaomin Luo, Wen Li, Lianlin Zeng, Yinxu Wang
Format: Article
Language:English
Published: Wiley 2025-06-01
Series:JOR Spine
Subjects:
inflammation
intervertebral disc degeneration
macrophages polarization
mechanism
treatment
Online Access:https://doi.org/10.1002/jsp2.70065
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https://doi.org/10.1002/jsp2.70065

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