Musculoskeletal Pain during the Menopausal Transition: A Systematic Review and Meta-Analysis
Musculoskeletal pain (MSP) is one of the most severe complaints in women undergoing menopause. The prevalence of MSP varied when taking the menopausal state and age factor into consideration. This study investigated the prevalence of MSP in perimenopausal women and its association with menopausal st...
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| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2020/8842110 |
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| author | Chang-bo Lu Peng-fei Liu Yong-sheng Zhou Fan-cheng Meng Tian-yun Qiao Xiao-jiang Yang Xu-yang Li Qian Xue Hui Xu Ya Liu Yong Han Yang Zhang |
| author_facet | Chang-bo Lu Peng-fei Liu Yong-sheng Zhou Fan-cheng Meng Tian-yun Qiao Xiao-jiang Yang Xu-yang Li Qian Xue Hui Xu Ya Liu Yong Han Yang Zhang |
| author_sort | Chang-bo Lu |
| collection | DOAJ |
| description | Musculoskeletal pain (MSP) is one of the most severe complaints in women undergoing menopause. The prevalence of MSP varied when taking the menopausal state and age factor into consideration. This study investigated the prevalence of MSP in perimenopausal women and its association with menopausal state. The MEDLINE, Embase, Web of Science, and PubMed databases were searched from inception to July 2020, and 16 studies were retrieved for the current meta-analysis. The primary outcome measure was the MSP Odds Ratio (OR). The estimated overall prevalence of MSP among perimenopausal women was 71% (4144 out of 5836, 95% confidence interval (CI): 64%-78%). Perimenopausal women demonstrated a higher risk for MSP than premenopausal ones (OR: 1.63, 95% CI: 1.35-1.96, P=0.008, I2=59.7%), but similar to that in postmenopausal ones (OR: 1.07, 95% CI: 0.95–1.20, P=0.316, I2=13.4%). The postmenopausal women were at a higher risk of moderate/severe MSP than the premenopausal ones (OR: 1.45, 95% CI: 1.21-1.75, P=0.302, I2=16.5%) or the perimenopausal ones (OR: 1.40, 95% CI: 1.09–1.79, P=0.106, I2=55.4%). In conclusion, the perimenopause is a state during which women are particularly predisposed to develop MSP. As to moderate to severe degrees of MSP, the odds increase linearly with age, from premenopause to peri- and then to postmenopause. |
| format | Article |
| id | doaj-art-7d52d1f9c0fa49d4ba77058130f81d34 |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-7d52d1f9c0fa49d4ba77058130f81d342025-02-03T01:28:18ZengWileyNeural Plasticity2090-59041687-54432020-01-01202010.1155/2020/88421108842110Musculoskeletal Pain during the Menopausal Transition: A Systematic Review and Meta-AnalysisChang-bo Lu0Peng-fei Liu1Yong-sheng Zhou2Fan-cheng Meng3Tian-yun Qiao4Xiao-jiang Yang5Xu-yang Li6Qian Xue7Hui Xu8Ya Liu9Yong Han10Yang Zhang11Departments of Orthopaedic Surgery, Xijing Hospital, Fourth Military Medical University, Xi’an, Shanxi 710032, ChinaDepartments of Urinary Surgery, Xijing Hospital, Fourth Military Medical University, Xi’an, Shanxi 710032, ChinaDepartment of Thoracic Surgery, Tangdu Hospital, Fourth Military Medical University, Xi’an, Shanxi 710038, ChinaDepartment of Thoracic Surgery, Tangdu Hospital, Fourth Military Medical University, Xi’an, Shanxi 710038, ChinaDepartment of Thoracic Surgery, Tangdu Hospital, Fourth Military Medical University, Xi’an, Shanxi 710038, ChinaDepartments of Orthopaedic Surgery, Xijing Hospital, Fourth Military Medical University, Xi’an, Shanxi 710032, ChinaDepartment of Neurobiology and Collaborative Innovation Center for Brain Science, School of Basic Medicine, Fourth Military Medical University, Xi’an, Shanxi 710032, ChinaDepartment of Neurobiology and Collaborative Innovation Center for Brain Science, School of Basic Medicine, Fourth Military Medical University, Xi’an, Shanxi 710032, ChinaDepartment of Neurobiology and Collaborative Innovation Center for Brain Science, School of Basic Medicine, Fourth Military Medical University, Xi’an, Shanxi 710032, ChinaDepartment of Out-Patient, Xijing Hospital, Fourth Military Medical University, Xi’an, Shaanxi 710032, ChinaDepartment of Thoracic Surgery, Tangdu Hospital, Fourth Military Medical University, Xi’an, Shanxi 710038, ChinaDepartments of Orthopaedic Surgery, Xijing Hospital, Fourth Military Medical University, Xi’an, Shanxi 710032, ChinaMusculoskeletal pain (MSP) is one of the most severe complaints in women undergoing menopause. The prevalence of MSP varied when taking the menopausal state and age factor into consideration. This study investigated the prevalence of MSP in perimenopausal women and its association with menopausal state. The MEDLINE, Embase, Web of Science, and PubMed databases were searched from inception to July 2020, and 16 studies were retrieved for the current meta-analysis. The primary outcome measure was the MSP Odds Ratio (OR). The estimated overall prevalence of MSP among perimenopausal women was 71% (4144 out of 5836, 95% confidence interval (CI): 64%-78%). Perimenopausal women demonstrated a higher risk for MSP than premenopausal ones (OR: 1.63, 95% CI: 1.35-1.96, P=0.008, I2=59.7%), but similar to that in postmenopausal ones (OR: 1.07, 95% CI: 0.95–1.20, P=0.316, I2=13.4%). The postmenopausal women were at a higher risk of moderate/severe MSP than the premenopausal ones (OR: 1.45, 95% CI: 1.21-1.75, P=0.302, I2=16.5%) or the perimenopausal ones (OR: 1.40, 95% CI: 1.09–1.79, P=0.106, I2=55.4%). In conclusion, the perimenopause is a state during which women are particularly predisposed to develop MSP. As to moderate to severe degrees of MSP, the odds increase linearly with age, from premenopause to peri- and then to postmenopause.http://dx.doi.org/10.1155/2020/8842110 |
| spellingShingle | Chang-bo Lu Peng-fei Liu Yong-sheng Zhou Fan-cheng Meng Tian-yun Qiao Xiao-jiang Yang Xu-yang Li Qian Xue Hui Xu Ya Liu Yong Han Yang Zhang Musculoskeletal Pain during the Menopausal Transition: A Systematic Review and Meta-Analysis Neural Plasticity |
| title | Musculoskeletal Pain during the Menopausal Transition: A Systematic Review and Meta-Analysis |
| title_full | Musculoskeletal Pain during the Menopausal Transition: A Systematic Review and Meta-Analysis |
| title_fullStr | Musculoskeletal Pain during the Menopausal Transition: A Systematic Review and Meta-Analysis |
| title_full_unstemmed | Musculoskeletal Pain during the Menopausal Transition: A Systematic Review and Meta-Analysis |
| title_short | Musculoskeletal Pain during the Menopausal Transition: A Systematic Review and Meta-Analysis |
| title_sort | musculoskeletal pain during the menopausal transition a systematic review and meta analysis |
| url | http://dx.doi.org/10.1155/2020/8842110 |
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