Molecular mechanisms explaining sex-specific functional connectivity changes in chronic insomnia disorder

Molecular mechanisms explaining sex-specific functional connectivity changes in chronic insomnia disorder

Abstract Background This study investigates the hypothesis that chronic insomnia disorder (CID) is characterized by sex-specific changes in resting-state functional connectivity (rsFC), with certain molecular mechanisms potentially influencing CID's pathophysiology by altering rsFC in relevant...

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Bibliographic Details
Main Authors: Liyong Yu, Zhifu Shen, Wei Wei, Zeyang Dou, Yucai Luo, Daijie Hu, Wenting Lin, Guangli Zhao, Xiaojuan Hong, Siyi Yu
Format: Article
Language:English
Published: BMC 2025-05-01
Series:BMC Medicine
Subjects:
Chronic insomnia
Functional connectivity
Default mode network
Sex-specific effects
Transcriptional signatures
Machine learning
Online Access:https://doi.org/10.1186/s12916-025-04089-9
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https://doi.org/10.1186/s12916-025-04089-9

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