High fructose rewires gut glucose sensing via glucagon-like peptide 2 to impair metabolic regulation in mice

High fructose rewires gut glucose sensing via glucagon-like peptide 2 to impair metabolic regulation in mice

Objective: Increased fructose consumption contributes to type 2 diabetes (T2D) and metabolic dysfunction-associated steatotic liver disease (MASLD), but the mechanisms are ill-defined. Gut nutrient sensing involves enterohormones like Glucagon-like peptide (Glp)2, which regulates the absorptive capa...

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Bibliographic Details
Main Authors: Eya Sellami, Paulo Henrique Evangelista-Silva, Caio Jordão Teixeira, Khoudia Diop, Patricia Mitchell, Fernando Forato Anhê
Format: Article
Language:English
Published: Elsevier 2025-03-01
Series:Molecular Metabolism
Subjects:
Glucagon-like peptide 2
Glucagon-like peptide 2 receptor
Type 2 diabetes
Obesity
Sugar
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877825000080
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