Surface Modification of Biomaterials: A Quest for Blood Compatibility
Cardiovascular implants must resist thrombosis and intimal hyperplasia to maintain patency. These implants when in contact with blood face a challenge to oppose the natural coagulation process that becomes activated. Surface protein adsorption and their relevant 3D confirmation greatly determine the...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2012-01-01
|
| Series: | International Journal of Biomaterials |
| Online Access: | http://dx.doi.org/10.1155/2012/707863 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832558872377688064 |
|---|---|
| author | Achala de Mel Brian G. Cousins Alexander M. Seifalian |
| author_facet | Achala de Mel Brian G. Cousins Alexander M. Seifalian |
| author_sort | Achala de Mel |
| collection | DOAJ |
| description | Cardiovascular implants must resist thrombosis and intimal hyperplasia to maintain patency. These implants when in contact with blood face a challenge to oppose the natural coagulation process that becomes activated. Surface protein adsorption and their relevant 3D confirmation greatly determine the degree of blood compatibility. A great deal of research efforts are attributed towards realising such a surface, which comprise of a range of methods on surface modification. Surface modification methods can be broadly categorized as physicochemical modifications and biological modifications. These modifications aim to modulate platelet responses directly through modulation of thrombogenic proteins or by inducing antithrombogenic biomolecules that can be biofunctionalised onto surfaces or through inducing an active endothelium. Nanotechnology is recognising a great role in such surface modification of cardiovascular implants through biofunctionalisation of polymers and peptides in nanocomposites and through nanofabrication of polymers which will pave the way for finding a closer blood match through haemostasis when developing cardiovascular implants with a greater degree of patency. |
| format | Article |
| id | doaj-art-7d13fb1767be4e48a73a0bdeca3936e0 |
| institution | Kabale University |
| issn | 1687-8787 1687-8795 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Biomaterials |
| spelling | doaj-art-7d13fb1767be4e48a73a0bdeca3936e02025-02-03T01:31:23ZengWileyInternational Journal of Biomaterials1687-87871687-87952012-01-01201210.1155/2012/707863707863Surface Modification of Biomaterials: A Quest for Blood CompatibilityAchala de Mel0Brian G. Cousins1Alexander M. Seifalian2UCL Centre for Nanotechnology & Regenerative Medicine, University College London, Pond Street, London NW3 2QG, UKUCL Centre for Nanotechnology & Regenerative Medicine, University College London, Pond Street, London NW3 2QG, UKUCL Centre for Nanotechnology & Regenerative Medicine, University College London, Pond Street, London NW3 2QG, UKCardiovascular implants must resist thrombosis and intimal hyperplasia to maintain patency. These implants when in contact with blood face a challenge to oppose the natural coagulation process that becomes activated. Surface protein adsorption and their relevant 3D confirmation greatly determine the degree of blood compatibility. A great deal of research efforts are attributed towards realising such a surface, which comprise of a range of methods on surface modification. Surface modification methods can be broadly categorized as physicochemical modifications and biological modifications. These modifications aim to modulate platelet responses directly through modulation of thrombogenic proteins or by inducing antithrombogenic biomolecules that can be biofunctionalised onto surfaces or through inducing an active endothelium. Nanotechnology is recognising a great role in such surface modification of cardiovascular implants through biofunctionalisation of polymers and peptides in nanocomposites and through nanofabrication of polymers which will pave the way for finding a closer blood match through haemostasis when developing cardiovascular implants with a greater degree of patency.http://dx.doi.org/10.1155/2012/707863 |
| spellingShingle | Achala de Mel Brian G. Cousins Alexander M. Seifalian Surface Modification of Biomaterials: A Quest for Blood Compatibility International Journal of Biomaterials |
| title | Surface Modification of Biomaterials: A Quest for Blood Compatibility |
| title_full | Surface Modification of Biomaterials: A Quest for Blood Compatibility |
| title_fullStr | Surface Modification of Biomaterials: A Quest for Blood Compatibility |
| title_full_unstemmed | Surface Modification of Biomaterials: A Quest for Blood Compatibility |
| title_short | Surface Modification of Biomaterials: A Quest for Blood Compatibility |
| title_sort | surface modification of biomaterials a quest for blood compatibility |
| url | http://dx.doi.org/10.1155/2012/707863 |
| work_keys_str_mv | AT achalademel surfacemodificationofbiomaterialsaquestforbloodcompatibility AT briangcousins surfacemodificationofbiomaterialsaquestforbloodcompatibility AT alexandermseifalian surfacemodificationofbiomaterialsaquestforbloodcompatibility |