Non-invasive assessment of stem cell DNA integrity in response to environmental stressors

Non-invasive assessment of stem cell DNA integrity in response to environmental stressors

Abstract The maintenance of DNA integrity in spermatogonial stem cells (SSCs) is essential for ensuring genetic stability and proper function in male germline cells. Here, we established a non-invasive approach to evaluate SSC DNA integrity and investigated the impact of detrimental environmental st...

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Bibliographic Details
Main Authors: Juan Wang, Yue Zhou, Lifan Zhuo, Bei Yan, Lianghong Ma
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Spermatogonial stem cells
Non-invasive detection
Heat stress
Probe biosensor
Mean number of DNA breakpoint
Reactive oxygen species
Online Access:https://doi.org/10.1038/s41598-025-00701-3
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https://doi.org/10.1038/s41598-025-00701-3

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