An adenosine analog shows high antiviral potency against coronavirus and arenavirus mainly through an unusual base pairing mode

An adenosine analog shows high antiviral potency against coronavirus and arenavirus mainly through an unusual base pairing mode

Abstract By targeting the essential viral RNA-dependent RNA polymerase (RdRP), nucleoside analogs (NAs) have exhibited great potential in antiviral therapy for RNA virus-related diseases. However, most ribose-modified NAs do not present broad-spectrum features, likely due to differences in ribose-Rd...

Full description

Saved in:
Bibliographic Details
Main Authors: Xiaoying Jia, Xuping Jing, Ming Li, Minli Gao, Yao Zhong, Entao Li, Yang Liu, Rui Li, Guoqiang Yao, Qiaojie Liu, Minmin Zhou, Yuxia Hou, Linfeng An, Yibao Hong, Shanshan Li, Jiancun Zhang, Wei Wang, Kaiming Zhang, Peng Gong, Sandra Chiu
Format: Article
Language:English
Published: Nature Portfolio 2024-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-54918-3
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doi.org/10.1038/s41467-024-54918-3

Similar Items