The magnitude of exercise‐induced progenitor cell mobilisation and extravasation is positively associated with cardiorespiratory fitness
Abstract CD34+ progenitor cells with angiogenic capabilities traffic into blood during exercise and extravasate afterwards but the magnitude of this response varies between people. We examined whether exercise‐induced progenitor cell trafficking is influenced by cardiorespiratory fitness (maximum ox...
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| Format: | Article |
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Wiley
2025-02-01
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| Series: | Experimental Physiology |
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| Online Access: | https://doi.org/10.1113/EP092041 |
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| author | Mark Ross Sarah Aldred Mark T. Drayson Jos A. Bosch James E. Turner |
| author_facet | Mark Ross Sarah Aldred Mark T. Drayson Jos A. Bosch James E. Turner |
| author_sort | Mark Ross |
| collection | DOAJ |
| description | Abstract CD34+ progenitor cells with angiogenic capabilities traffic into blood during exercise and extravasate afterwards but the magnitude of this response varies between people. We examined whether exercise‐induced progenitor cell trafficking is influenced by cardiorespiratory fitness (maximum oxygen uptake; V̇O2max). Ten males (age: 23 ± 3 years; V̇O2max: 61.88 ± 4.68 mL kg min−1) undertook 1 h of treadmill running at 80% of V̇O2max. Blood samples were collected before exercise (Pre), in the final minute of exercise (0 h) and afterwards at 0.25, 1 and 24 h. Pan‐progenitor cells (CD34+, CD34+CD45dim) and putative endothelial progenitor cells (CD34+CD133+, CD34+VEGFR2+, CD34+CD45dimVEGFR2+) were quantified using flow cytometry. Progenitor subpopulations (except for CD34+CD45dimVEGFR2+) increased at 0 h (P < 0.05) and returned to pre‐exercise levels by 1 h. V̇O2max was positively associated with the exercise‐induced progenitor cell response and there were statistically significant time × V̇O2max interactions for CD34+, CD34+CD45dim and CD34+CD133+ subpopulations but not VEGFR2‐expressing progenitor cells. There were statistically significant correlations between V̇O2max and ingress (r > 0.70, P < 0.025) and egress (r > −0.77, P < 0.009) of progenitor cell subsets (CD34+, CD34+CD45dim, CD34+CD133+), showing that cardiorespiratory fitness influences the magnitude of progenitor cell mobilisation into the blood and subsequent extravasation. These data may provide a link between high levels of cardiorespiratory fitness and vascular health. |
| format | Article |
| id | doaj-art-7cc6229f56d94cc19511c34026268105 |
| institution | Kabale University |
| issn | 0958-0670 1469-445X |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Wiley |
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| series | Experimental Physiology |
| spelling | doaj-art-7cc6229f56d94cc19511c340262681052025-01-31T06:19:50ZengWileyExperimental Physiology0958-06701469-445X2025-02-01110220621410.1113/EP092041The magnitude of exercise‐induced progenitor cell mobilisation and extravasation is positively associated with cardiorespiratory fitnessMark Ross0Sarah Aldred1Mark T. Drayson2Jos A. Bosch3James E. Turner4Institue of Life and Earth Sciences Heriot‐Watt University Edinburgh UKSchool of Sport, Exercise and Rehabilitation Sciences University of Birmingham Birmingham UKInstitute of Immunology and Immunotherapy University of Birmingham Birmingham UKDepartment of Clinical Psychology University of Amsterdam Amsterdam The NetherlandsSchool of Sport, Exercise and Rehabilitation Sciences University of Birmingham Birmingham UKAbstract CD34+ progenitor cells with angiogenic capabilities traffic into blood during exercise and extravasate afterwards but the magnitude of this response varies between people. We examined whether exercise‐induced progenitor cell trafficking is influenced by cardiorespiratory fitness (maximum oxygen uptake; V̇O2max). Ten males (age: 23 ± 3 years; V̇O2max: 61.88 ± 4.68 mL kg min−1) undertook 1 h of treadmill running at 80% of V̇O2max. Blood samples were collected before exercise (Pre), in the final minute of exercise (0 h) and afterwards at 0.25, 1 and 24 h. Pan‐progenitor cells (CD34+, CD34+CD45dim) and putative endothelial progenitor cells (CD34+CD133+, CD34+VEGFR2+, CD34+CD45dimVEGFR2+) were quantified using flow cytometry. Progenitor subpopulations (except for CD34+CD45dimVEGFR2+) increased at 0 h (P < 0.05) and returned to pre‐exercise levels by 1 h. V̇O2max was positively associated with the exercise‐induced progenitor cell response and there were statistically significant time × V̇O2max interactions for CD34+, CD34+CD45dim and CD34+CD133+ subpopulations but not VEGFR2‐expressing progenitor cells. There were statistically significant correlations between V̇O2max and ingress (r > 0.70, P < 0.025) and egress (r > −0.77, P < 0.009) of progenitor cell subsets (CD34+, CD34+CD45dim, CD34+CD133+), showing that cardiorespiratory fitness influences the magnitude of progenitor cell mobilisation into the blood and subsequent extravasation. These data may provide a link between high levels of cardiorespiratory fitness and vascular health.https://doi.org/10.1113/EP092041cardiorespiratory fitnessexerciseprogenitor cells |
| spellingShingle | Mark Ross Sarah Aldred Mark T. Drayson Jos A. Bosch James E. Turner The magnitude of exercise‐induced progenitor cell mobilisation and extravasation is positively associated with cardiorespiratory fitness Experimental Physiology cardiorespiratory fitness exercise progenitor cells |
| title | The magnitude of exercise‐induced progenitor cell mobilisation and extravasation is positively associated with cardiorespiratory fitness |
| title_full | The magnitude of exercise‐induced progenitor cell mobilisation and extravasation is positively associated with cardiorespiratory fitness |
| title_fullStr | The magnitude of exercise‐induced progenitor cell mobilisation and extravasation is positively associated with cardiorespiratory fitness |
| title_full_unstemmed | The magnitude of exercise‐induced progenitor cell mobilisation and extravasation is positively associated with cardiorespiratory fitness |
| title_short | The magnitude of exercise‐induced progenitor cell mobilisation and extravasation is positively associated with cardiorespiratory fitness |
| title_sort | magnitude of exercise induced progenitor cell mobilisation and extravasation is positively associated with cardiorespiratory fitness |
| topic | cardiorespiratory fitness exercise progenitor cells |
| url | https://doi.org/10.1113/EP092041 |
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