Mouse B cells engineered to express an anti-HPV antibody elicit anti-tumor T cell responses

Mouse B cells engineered to express an anti-HPV antibody elicit anti-tumor T cell responses

Transplantation of engineered B cells has demonstrated efficacy in HIV disease models. B cell engineering may also be utilized for the treatment of cancer. Recent studies have highlighted that B cell activity is associated with favorable clinical outcomes in oncology. In mice, polyclonal B cells hav...

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Bibliographic Details
Main Authors: Michal Guberman Bracha, Guy Biber, Natalie Zelikson, Sharon Shavit, Roy Avraham, Yaron Vagima, Débora Rosa Bublik, Yael Katz, Adi Barzel, Leah Natasha Klapper, Shmuel Hess, Alessio David Nahmad
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Immunology
Subjects:
B cell
antibody
cancer
cell therapy (CT)
tertiary lymphoid structures
genome editing
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1613879/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1613879/full

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