Unveiling the Mechanism of Deprotonation and Proton Transfer of DNA Polymerase Catalysis via Single‐Molecule Conductance

Unveiling the Mechanism of Deprotonation and Proton Transfer of DNA Polymerase Catalysis via Single‐Molecule Conductance

Abstract DNA polymerases (Pols) play important roles in the transmission of genetic information. Although the function and (de)regulation of Pols are linked to many human diseases, the key mechanism of 3′‐OH deprotonation and the PPi formation are not totally clear. In this work, a method is present...

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Bibliographic Details
Main Authors: Lihua Zhao, Yang Xu, Zhiheng Yang, Wenzhe Liu, Shichao Zhong, Jingwei Bai, Xuefeng Guo
Format: Article
Language:English
Published: Wiley 2025-01-01
Series:Advanced Science
Subjects:
catalysis mechanism
DNA polymerase
electric field
GMG biosensor
hPol β protein
single‐molecule level
Online Access:https://doi.org/10.1002/advs.202408112
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https://doi.org/10.1002/advs.202408112

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