心力衰竭大鼠脑脊液及血清瘦素改变的研究

【目的】检测心力衰竭大鼠血清、脑脊液瘦素水平及脑脊液/血清瘦素比值改变,对心衰大鼠的瘦素水平、瘦素抵抗及瘦素在血-脑脊液处的转运进行初步探讨。【方法】通过缩窄雄性Wistar大鼠腹主动脉制成心力衰竭模型。30只大鼠随机分成空白对照组、假手术对照组和心衰组。预实验应用超声心动图和血流动力学检测证实术后4个月大鼠已经出现明显心衰。术后4个月采集脑脊液、血清,ELISA法测定瘦素水平。【结果】心衰组的血清瘦素水平较假手术及空白对照组明显升高[(8.1±4.0)ng/mLvs(3.7±1.7)ng/mL,(3.1±1.4)ng/mL,P〈0.01]。3组脑脊液瘦素水平无显著差异。心衰组脑脊液/血清瘦素...

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Bibliographic Details
Main Authors: 冷秀玉, 曾武涛, 熊艳, 陈国伟, 王礼春
Format: Article
Language:zho
Published: Editorial Office of Journal of Sun Yat-sen University 2007-01-01
Series:Zhongshan Daxue xuebao. Yixue kexue ban
Subjects:
Online Access:http://xuebaoyx.sysu.edu.cn/zh/article/43581079/
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