Lentivirus-Mediated Missense Mutation in HtrA1 Leads to Activation of the TGF-β/Smads Pathway and Increased Apoptosis of Mouse Brain Microvascular Endothelial Cells via the Oxidative Stress Pathway

Lentivirus-Mediated Missense Mutation in HtrA1 Leads to Activation of the TGF-β/Smads Pathway and Increased Apoptosis of Mouse Brain Microvascular Endothelial Cells via the Oxidative Stress Pathway

Background: The aim of this study was to investigate the possible molecular mechanisms underlying cerebral small vessel disease caused by a missense mutation in the high-temperature serine peptidase A1 gene, HtrA1 (NM_002775.4, Exon4, c.905G>A, p.Arg302Gln). Stable strain model...

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Main Authors: Shi-na Song, Hui-juan Li, Jian-lin Liang, Qian-qian Ren, Chang-xin Li, Sui-yi Xu
Format: Article
Language:English
Published: IMR Press 2024-10-01
Series:Journal of Integrative Neuroscience
Subjects:
htra1
bend.3
tgf-β/smads
oxidative stress
Online Access:https://www.imrpress.com/journal/JIN/23/11/10.31083/j.jin2311201
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https://www.imrpress.com/journal/JIN/23/11/10.31083/j.jin2311201

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