The potential of three-dimensional printing for pediatric oral solid dosage forms
Pediatric patients often require individualized dosing of medicine due to their unique pharmacokinetic and developmental characteristics. Current methods for tailoring the dose of pediatric medications, such as tablet splitting or compounding liquid formulations, have limitations in terms of dosing...
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| Format: | Article |
| Language: | English |
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Sciendo
2024-06-01
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| Series: | Acta Pharmaceutica |
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| Online Access: | https://doi.org/10.2478/acph-2024-0012 |
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| _version_ | 1832545174619684864 |
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| author | Kreft Klemen Fanous Marina Möckel Volker |
| author_facet | Kreft Klemen Fanous Marina Möckel Volker |
| author_sort | Kreft Klemen |
| collection | DOAJ |
| description | Pediatric patients often require individualized dosing of medicine due to their unique pharmacokinetic and developmental characteristics. Current methods for tailoring the dose of pediatric medications, such as tablet splitting or compounding liquid formulations, have limitations in terms of dosing accuracy and palatability. This paper explores the potential of 3D printing as a solution to address the challenges and provide tailored doses of medication for each pediatric patient. The technological overview of 3D printing is discussed, highlighting various 3D printing technologies and their suitability for pharmaceutical applications. Several individualization options with the potential to improve adherence are discussed, such as individualized dosage, custom release kinetics, tablet shape, and palatability. To integrate the preparation of 3D printed medication at the point of care, a decentralized manufacturing model is proposed. In this setup, pharmaceutical companies would routinely provide materials and instructions for 3D printing, while specialized compounding centers or hospital pharmacies perform the printing of medication. In addition, clinical opportunities of 3D printing for dose-finding trials are emphasized. On the other hand, current challenges in adequate dosing, regulatory compliance, adherence to quality standards, and maintenance of intellectual property need to be addressed for 3D printing to close the gap in personalized oral medication. |
| format | Article |
| id | doaj-art-7c3f904234d8452ca27f526ce9b1aacf |
| institution | Kabale University |
| issn | 1846-9558 |
| language | English |
| publishDate | 2024-06-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Acta Pharmaceutica |
| spelling | doaj-art-7c3f904234d8452ca27f526ce9b1aacf2025-02-03T08:10:43ZengSciendoActa Pharmaceutica1846-95582024-06-0174222924810.2478/acph-2024-0012The potential of three-dimensional printing for pediatric oral solid dosage formsKreft Klemen0Fanous Marina1Möckel Volker21Lek Pharmaceuticals d.d., a Sandoz Company, 1000Ljubljana, Slovenia2Novartis Pharma AG, 4002BaselSwitzerland2Novartis Pharma AG, 4002BaselSwitzerlandPediatric patients often require individualized dosing of medicine due to their unique pharmacokinetic and developmental characteristics. Current methods for tailoring the dose of pediatric medications, such as tablet splitting or compounding liquid formulations, have limitations in terms of dosing accuracy and palatability. This paper explores the potential of 3D printing as a solution to address the challenges and provide tailored doses of medication for each pediatric patient. The technological overview of 3D printing is discussed, highlighting various 3D printing technologies and their suitability for pharmaceutical applications. Several individualization options with the potential to improve adherence are discussed, such as individualized dosage, custom release kinetics, tablet shape, and palatability. To integrate the preparation of 3D printed medication at the point of care, a decentralized manufacturing model is proposed. In this setup, pharmaceutical companies would routinely provide materials and instructions for 3D printing, while specialized compounding centers or hospital pharmacies perform the printing of medication. In addition, clinical opportunities of 3D printing for dose-finding trials are emphasized. On the other hand, current challenges in adequate dosing, regulatory compliance, adherence to quality standards, and maintenance of intellectual property need to be addressed for 3D printing to close the gap in personalized oral medication.https://doi.org/10.2478/acph-2024-00123d printingpersonalized dosage formspediatric medicationcompounded medicineadditive manufacturingdecentralized manufacturing |
| spellingShingle | Kreft Klemen Fanous Marina Möckel Volker The potential of three-dimensional printing for pediatric oral solid dosage forms Acta Pharmaceutica 3d printing personalized dosage forms pediatric medication compounded medicine additive manufacturing decentralized manufacturing |
| title | The potential of three-dimensional printing for pediatric oral solid dosage forms |
| title_full | The potential of three-dimensional printing for pediatric oral solid dosage forms |
| title_fullStr | The potential of three-dimensional printing for pediatric oral solid dosage forms |
| title_full_unstemmed | The potential of three-dimensional printing for pediatric oral solid dosage forms |
| title_short | The potential of three-dimensional printing for pediatric oral solid dosage forms |
| title_sort | potential of three dimensional printing for pediatric oral solid dosage forms |
| topic | 3d printing personalized dosage forms pediatric medication compounded medicine additive manufacturing decentralized manufacturing |
| url | https://doi.org/10.2478/acph-2024-0012 |
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