Evolutionary divergence in CTCF-mediated chromatin topology drives transcriptional innovation in humans

Evolutionary divergence in CTCF-mediated chromatin topology drives transcriptional innovation in humans

Abstract Chromatin topology can impact gene regulation, but how evolutionary divergence in chromatin topology has shaped gene regulatory landscapes for distinctive human traits remains poorly understood. CTCF sites determine chromatin topology by forming domains and loops. Here, we show evolutionary...

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Main Authors: Xia Wu, Dan Xiong, Rong Liu, Xingqiang Lai, Yuhan Tian, Ziying Xie, Li Chen, Lanqi Hu, Jingjing Duan, Xinyu Gao, Xian Zeng, Wei Dong, Ting Xu, Fang Fu, Xin Yang, Xinlai Cheng, Dariusz Plewczynski, Minji Kim, Wenjun Xin, Tianyun Wang, Andy Peng Xiang, Zhonghui Tang
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-58275-7
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