Brain penetration of peripheral extracellular vesicles from Alzheimer's patients and induction of microglia activation

Brain penetration of peripheral extracellular vesicles from Alzheimer's patients and induction of microglia activation

Abstract Alzheimer's disease (AD) is an age‐related neurodegenerative pathology. Brain‐derived extracellular vesicles (EVs) have been demonstrated to be implicated in AD pathogenesis by facilitating the propagation of Tau, amyloid‐β and inflammatory cytokines. However, the impact of peripheral...

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Main Authors: Hermine Counil, Rummenigge Oliveira Silva, Jean‐Michel Rabanel, Charlotte Zaouter, Mohamed Haddad, Mohamed Raâfet Ben Khedher, Davide Brambilla, Tamas Fülöp, Shunmoogum A. Patten, Charles Ramassamy
Format: Article
Language:English
Published: Wiley 2025-01-01
Series:Journal of Extracellular Biology
Subjects:
Alzheimer's disease
blood‐brain barrier
brain
extracellular vesicles
microglia
zebrafish
Online Access:https://doi.org/10.1002/jex2.70027
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https://doi.org/10.1002/jex2.70027

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