A multiplexed LC-MS/MS assay for comprehensive screening of amino acid metabolism disorders

A multiplexed LC-MS/MS assay for comprehensive screening of amino acid metabolism disorders

Advancements in liquid chromatography-tandem mass spectrometry (LC-MS/MS) are redefining the landscape of clinical diagnostics, particularly in the context of newborn screening for inborn errors of metabolism. Conventional analytical platforms are often limited by a small number of analytes and requ...

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Bibliographic Details
Main Authors: Jisha Chandran, Madan Gopal Ramarajan, Vykuntaraju Kammasandra Nanjundagowda, Aruna Gowdra, Jayesh Warade, Anikha Bellad, Kannan Rangiah
Format: Article
Language:English
Published: Elsevier 2025-12-01
Series:Talanta Open
Subjects:
Amino acid
Amines
Quantification
LC-MS
Newborn Screening
Inborn errors of metabolism
Online Access:http://www.sciencedirect.com/science/article/pii/S2666831925001250
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