Vitamin B12 Deficiency due to Chlorofluorocarbon: A Case Report

Background. Vitamin B12 is vital for optimal functioning of various organ systems but more importantly the central nervous system and the hematological system. Deficiency of vitamin B12 clinically manifests as excessive daytime fatigue, memory difficulties, encephalopathy, myelopathy, peripheral neu...

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Main Authors: Hemlata Bhaskar, Rekha Chaudhary
Format: Article
Language:English
Published: Wiley 2010-01-01
Series:Case Reports in Medicine
Online Access:http://dx.doi.org/10.1155/2010/691563
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author Hemlata Bhaskar
Rekha Chaudhary
author_facet Hemlata Bhaskar
Rekha Chaudhary
author_sort Hemlata Bhaskar
collection DOAJ
description Background. Vitamin B12 is vital for optimal functioning of various organ systems but more importantly the central nervous system and the hematological system. Deficiency of vitamin B12 clinically manifests as excessive daytime fatigue, memory difficulties, encephalopathy, myelopathy, peripheral neuropathy, and optic neuropathy. In occupational medicine, vitamin B12 deficiency has been reported with exposure to nitrous oxide in health care workers. However, not much is known about exposure to Freons in other industries and vitamin B12 deficiency. Aim. We are reporting a case of vitamin B12 deficiency in the setting of exposure to chlorofluorocarbon (CFC) gases. Case Report. A 55-year-old male refrigerator mechanic experienced recurrent visual symptoms, which included diplopia and blurring. A complete workup was done and was significant of vitamin B12 deficiency. However, his B12 levels were refractory to supplementation. Appropriate precautions at workplace improved patient's symptoms and were associated with significant improvement in B12 levels. Conclusion. To the best of our knowledge, this is the first reported case of vitamin B12 deficiency (that remains refractory to supplementation) in the setting of exposure to Freon gases.
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spelling doaj-art-7bf4b1790c9645a79f4b5f14824f40b82025-02-03T01:24:18ZengWileyCase Reports in Medicine1687-96271687-96352010-01-01201010.1155/2010/691563691563Vitamin B12 Deficiency due to Chlorofluorocarbon: A Case ReportHemlata Bhaskar0Rekha Chaudhary1Department of Medicine, The University of Toledo, 3000 Arlington Avenue Toledo, OH 43614, USADivision of Hematology and Oncology, The University of Toledo, 3000 Arlington Avenue Toledo, OH 43614, USABackground. Vitamin B12 is vital for optimal functioning of various organ systems but more importantly the central nervous system and the hematological system. Deficiency of vitamin B12 clinically manifests as excessive daytime fatigue, memory difficulties, encephalopathy, myelopathy, peripheral neuropathy, and optic neuropathy. In occupational medicine, vitamin B12 deficiency has been reported with exposure to nitrous oxide in health care workers. However, not much is known about exposure to Freons in other industries and vitamin B12 deficiency. Aim. We are reporting a case of vitamin B12 deficiency in the setting of exposure to chlorofluorocarbon (CFC) gases. Case Report. A 55-year-old male refrigerator mechanic experienced recurrent visual symptoms, which included diplopia and blurring. A complete workup was done and was significant of vitamin B12 deficiency. However, his B12 levels were refractory to supplementation. Appropriate precautions at workplace improved patient's symptoms and were associated with significant improvement in B12 levels. Conclusion. To the best of our knowledge, this is the first reported case of vitamin B12 deficiency (that remains refractory to supplementation) in the setting of exposure to Freon gases.http://dx.doi.org/10.1155/2010/691563
spellingShingle Hemlata Bhaskar
Rekha Chaudhary
Vitamin B12 Deficiency due to Chlorofluorocarbon: A Case Report
Case Reports in Medicine
title Vitamin B12 Deficiency due to Chlorofluorocarbon: A Case Report
title_full Vitamin B12 Deficiency due to Chlorofluorocarbon: A Case Report
title_fullStr Vitamin B12 Deficiency due to Chlorofluorocarbon: A Case Report
title_full_unstemmed Vitamin B12 Deficiency due to Chlorofluorocarbon: A Case Report
title_short Vitamin B12 Deficiency due to Chlorofluorocarbon: A Case Report
title_sort vitamin b12 deficiency due to chlorofluorocarbon a case report
url http://dx.doi.org/10.1155/2010/691563
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