Clinically Significant Minor Blood Group Antigens amongst North Indian Donor Population
Background. Racial differences in blood group antigen distribution are common and may result in striking and interesting findings. These differences in blood group antigen distribution are important due to their influence on the clinical practice of transfusion medicine. Study Design and Methods. Th...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Advances in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2013/215454 |
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| author | Divjot Singh Lamba Ravneet Kaur Sabita Basu |
| author_facet | Divjot Singh Lamba Ravneet Kaur Sabita Basu |
| author_sort | Divjot Singh Lamba |
| collection | DOAJ |
| description | Background. Racial differences in blood group antigen distribution are common and may result in striking and interesting findings. These differences in blood group antigen distribution are important due to their influence on the clinical practice of transfusion medicine. Study Design and Methods. This is a prospective study, involving 1000 healthy regular repeat voluntary blood donors associated with the department. The clinically significant minor blood group antigens of these donors were studied. Results. Out of 1000 healthy regular repeat voluntary blood donors, 93% were D positive and 2.8% were K positive. Amongst the Rh antigens, e was the most common (99%), followed by D (93%), C (85.1%), c (62.3%), and E (21.5%). Within the MNS blood group system, antigen frequency was M (88%), N (57.5%), S (57.8%), and s (87.5%). Within the Duffy blood group system, antigen frequency was Fya (87.3%) and Fyb (58.3%). Conclusions. This data base will help us to prevent alloimmunisation in young females, pregnant women, and patients who are expected to require repeated transfusions in life by providing them with antigen matched blood. Antigen negative blood can also be made available without delay to already alloimmunized multitransfused patients. |
| format | Article |
| id | doaj-art-7bca64bb385e4566a1a1db349de8ca58 |
| institution | Kabale University |
| issn | 1687-9104 1687-9112 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advances in Hematology |
| spelling | doaj-art-7bca64bb385e4566a1a1db349de8ca582025-02-03T00:59:02ZengWileyAdvances in Hematology1687-91041687-91122013-01-01201310.1155/2013/215454215454Clinically Significant Minor Blood Group Antigens amongst North Indian Donor PopulationDivjot Singh Lamba0Ravneet Kaur1Sabita Basu2Department of Transfusion Medicine, Block D, Level II, Government Medical College & Hospital, Chandigarh 160030, IndiaDepartment of Transfusion Medicine, Block D, Level II, Government Medical College & Hospital, Chandigarh 160030, IndiaDepartment of Transfusion Medicine, Block D, Level II, Government Medical College & Hospital, Chandigarh 160030, IndiaBackground. Racial differences in blood group antigen distribution are common and may result in striking and interesting findings. These differences in blood group antigen distribution are important due to their influence on the clinical practice of transfusion medicine. Study Design and Methods. This is a prospective study, involving 1000 healthy regular repeat voluntary blood donors associated with the department. The clinically significant minor blood group antigens of these donors were studied. Results. Out of 1000 healthy regular repeat voluntary blood donors, 93% were D positive and 2.8% were K positive. Amongst the Rh antigens, e was the most common (99%), followed by D (93%), C (85.1%), c (62.3%), and E (21.5%). Within the MNS blood group system, antigen frequency was M (88%), N (57.5%), S (57.8%), and s (87.5%). Within the Duffy blood group system, antigen frequency was Fya (87.3%) and Fyb (58.3%). Conclusions. This data base will help us to prevent alloimmunisation in young females, pregnant women, and patients who are expected to require repeated transfusions in life by providing them with antigen matched blood. Antigen negative blood can also be made available without delay to already alloimmunized multitransfused patients.http://dx.doi.org/10.1155/2013/215454 |
| spellingShingle | Divjot Singh Lamba Ravneet Kaur Sabita Basu Clinically Significant Minor Blood Group Antigens amongst North Indian Donor Population Advances in Hematology |
| title | Clinically Significant Minor Blood Group Antigens amongst North Indian Donor Population |
| title_full | Clinically Significant Minor Blood Group Antigens amongst North Indian Donor Population |
| title_fullStr | Clinically Significant Minor Blood Group Antigens amongst North Indian Donor Population |
| title_full_unstemmed | Clinically Significant Minor Blood Group Antigens amongst North Indian Donor Population |
| title_short | Clinically Significant Minor Blood Group Antigens amongst North Indian Donor Population |
| title_sort | clinically significant minor blood group antigens amongst north indian donor population |
| url | http://dx.doi.org/10.1155/2013/215454 |
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