Polymorphism in LEP and LEPR May Modify Leptin Levels and Represent Risk Factors for Thyroid Cancer
Purpose. To understand the role of polymorphisms in the LEP (rs7799039 and rs2167270) and LEPR (rs1137101 and rs1137100) genes in DTC susceptibility and their effect on leptin levels. Methods. We studied 153 patients with DTC and 234 controls through TaqMan SNP Genotyping and ELISA, comparing these...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2015/173218 |
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| author | Marjory Alana Marcello Antonio Ramos Calixto Jacqueline Fatima Martins de Almeida Mariana Bonjiorno Martins Lucas Leite Cunha Camila Ayume Amano Cavalari Elba C. S. Etchebehere Ligia Vera Montalli da Assumpção Bruno Geloneze Andre Lopes Carvalho Laura Sterian Ward |
| author_facet | Marjory Alana Marcello Antonio Ramos Calixto Jacqueline Fatima Martins de Almeida Mariana Bonjiorno Martins Lucas Leite Cunha Camila Ayume Amano Cavalari Elba C. S. Etchebehere Ligia Vera Montalli da Assumpção Bruno Geloneze Andre Lopes Carvalho Laura Sterian Ward |
| author_sort | Marjory Alana Marcello |
| collection | DOAJ |
| description | Purpose. To understand the role of polymorphisms in the LEP (rs7799039 and rs2167270) and LEPR (rs1137101 and rs1137100) genes in DTC susceptibility and their effect on leptin levels. Methods. We studied 153 patients with DTC and 234 controls through TaqMan SNP Genotyping and ELISA, comparing these data to the clinicopathological data of patients with DTC. Results. Patients with AA genotype of rs7799039 had higher levels of serum leptin (9.22±0.98 ng/mL) than those with AG genotype (10.07±0.60 ng/mL; P=0.005). Individuals with AG genotype of rs2167270 also produced higher serum leptin levels (10.05±0.59 ng/mL) than the subjects with GG genotype (9.52±0.79 ng/mL; P<0.05). A multivariate logistic regression adjusted for gender, age, and BMI showed that the AG genotype of rs7799039 was an independent risk for DTC (OR, 11.689; P=0.0183; 95% CI, 1.516–90.119). Similarly, AG and GG genotypes of rs1137101 increased the susceptibility to DTC (OR, 3.747; P=0.027; 95% CI, 1.161–12.092 and OR, 5.437; P=0.013; 95% CI, 1.426–20.729). Conclusions. We demonstrated that rs7799039 and rs2167270 polymorphisms modify the serum leptin concentrations in patients with DTC. Furthermore, polymorphisms rs7799039 and rs1137101 increase the risk of DTC development, although they do not correlate with tumor aggressiveness. |
| format | Article |
| id | doaj-art-7b91a528f4514d19b6a1291d1f3d29cd |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-7b91a528f4514d19b6a1291d1f3d29cd2025-02-03T06:11:29ZengWileyInternational Journal of Endocrinology1687-83371687-83452015-01-01201510.1155/2015/173218173218Polymorphism in LEP and LEPR May Modify Leptin Levels and Represent Risk Factors for Thyroid CancerMarjory Alana Marcello0Antonio Ramos Calixto1Jacqueline Fatima Martins de Almeida2Mariana Bonjiorno Martins3Lucas Leite Cunha4Camila Ayume Amano Cavalari5Elba C. S. Etchebehere6Ligia Vera Montalli da Assumpção7Bruno Geloneze8Andre Lopes Carvalho9Laura Sterian Ward10Laboratory of Cancer Molecular Genetics (Gemoca), Faculty of Medical Sciences, University of Campinas (FCM-Unicamp), Rua Tessalia Vieira de Camargo 126, 13083-970 Campinas, SP, BrazilLaboratory of Investigation on Metabolism and Diabetes (LIMED), Faculty of Medical Sciences, University of Campinas (FCM-Unicamp), Rua Carlos Chagas 420, 13083-878 Campinas, SP, BrazilLaboratory of Cancer Molecular Genetics (Gemoca), Faculty of Medical Sciences, University of Campinas (FCM-Unicamp), Rua Tessalia Vieira de Camargo 126, 13083-970 Campinas, SP, BrazilLaboratory of Cancer Molecular Genetics (Gemoca), Faculty of Medical Sciences, University of Campinas (FCM-Unicamp), Rua Tessalia Vieira de Camargo 126, 13083-970 Campinas, SP, BrazilLaboratory of Cancer Molecular Genetics (Gemoca), Faculty of Medical Sciences, University of Campinas (FCM-Unicamp), Rua Tessalia Vieira de Camargo 126, 13083-970 Campinas, SP, BrazilLaboratory of Cancer Molecular Genetics (Gemoca), Faculty of Medical Sciences, University of Campinas (FCM-Unicamp), Rua Tessalia Vieira de Camargo 126, 13083-970 Campinas, SP, BrazilService of Nuclear Medicine, University of Campinas, Rua Vital Brasil 251, 13083-888 Campinas, SP, BrazilService of Endocrinology, University of Campinas, Rua Vital Brasil 251, 13083-888 Campinas, SP, BrazilLaboratory of Investigation on Metabolism and Diabetes (LIMED), Faculty of Medical Sciences, University of Campinas (FCM-Unicamp), Rua Carlos Chagas 420, 13083-878 Campinas, SP, BrazilDepartment of Head and Neck Surgery, Barretos Cancer Hospital, Rua Antenor Duarte Vilela 1331, 14784-400 Barretos, SP, BrazilLaboratory of Cancer Molecular Genetics (Gemoca), Faculty of Medical Sciences, University of Campinas (FCM-Unicamp), Rua Tessalia Vieira de Camargo 126, 13083-970 Campinas, SP, BrazilPurpose. To understand the role of polymorphisms in the LEP (rs7799039 and rs2167270) and LEPR (rs1137101 and rs1137100) genes in DTC susceptibility and their effect on leptin levels. Methods. We studied 153 patients with DTC and 234 controls through TaqMan SNP Genotyping and ELISA, comparing these data to the clinicopathological data of patients with DTC. Results. Patients with AA genotype of rs7799039 had higher levels of serum leptin (9.22±0.98 ng/mL) than those with AG genotype (10.07±0.60 ng/mL; P=0.005). Individuals with AG genotype of rs2167270 also produced higher serum leptin levels (10.05±0.59 ng/mL) than the subjects with GG genotype (9.52±0.79 ng/mL; P<0.05). A multivariate logistic regression adjusted for gender, age, and BMI showed that the AG genotype of rs7799039 was an independent risk for DTC (OR, 11.689; P=0.0183; 95% CI, 1.516–90.119). Similarly, AG and GG genotypes of rs1137101 increased the susceptibility to DTC (OR, 3.747; P=0.027; 95% CI, 1.161–12.092 and OR, 5.437; P=0.013; 95% CI, 1.426–20.729). Conclusions. We demonstrated that rs7799039 and rs2167270 polymorphisms modify the serum leptin concentrations in patients with DTC. Furthermore, polymorphisms rs7799039 and rs1137101 increase the risk of DTC development, although they do not correlate with tumor aggressiveness.http://dx.doi.org/10.1155/2015/173218 |
| spellingShingle | Marjory Alana Marcello Antonio Ramos Calixto Jacqueline Fatima Martins de Almeida Mariana Bonjiorno Martins Lucas Leite Cunha Camila Ayume Amano Cavalari Elba C. S. Etchebehere Ligia Vera Montalli da Assumpção Bruno Geloneze Andre Lopes Carvalho Laura Sterian Ward Polymorphism in LEP and LEPR May Modify Leptin Levels and Represent Risk Factors for Thyroid Cancer International Journal of Endocrinology |
| title | Polymorphism in LEP and LEPR May Modify Leptin Levels and Represent Risk Factors for Thyroid Cancer |
| title_full | Polymorphism in LEP and LEPR May Modify Leptin Levels and Represent Risk Factors for Thyroid Cancer |
| title_fullStr | Polymorphism in LEP and LEPR May Modify Leptin Levels and Represent Risk Factors for Thyroid Cancer |
| title_full_unstemmed | Polymorphism in LEP and LEPR May Modify Leptin Levels and Represent Risk Factors for Thyroid Cancer |
| title_short | Polymorphism in LEP and LEPR May Modify Leptin Levels and Represent Risk Factors for Thyroid Cancer |
| title_sort | polymorphism in lep and lepr may modify leptin levels and represent risk factors for thyroid cancer |
| url | http://dx.doi.org/10.1155/2015/173218 |
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